11-Azido-3,6,9-trioxaundecanoic Acid - CAS 172531-37-2

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N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl/ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

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Molecular Formula C8H15N3O5
Molecular Weight 233.22

11-Azido-3,6,9-trioxaundecanoic Acid

Synonyms 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid; 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid
Solubility 10 mM in DMSO
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping Room temperature in continental US; may vary elsewhere
InChI Key GIXBCECBLAEYKA-UHFFFAOYSA-N
InChI InChI=1S/C8H15N3O5/c9-11-10-1-2-14-3-4-15-5-6-16-7-8(12)13/h1-7H2,(H,12,13)
Canonical SMILES C(COCCOCCOCC(=O)O)N=[N+]=[N-]

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