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AT-7519 - CAS 844442-38-2

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AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

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Molecular Formula

C16H17Cl2N5O2

Molecular Weight

382.24

AT-7519

- Specification
  - Related CAS
    
    902135-91-5 (hydrochloride) 1431697-85-6 (trifluoroacetate)
    
    Purity
    
    0.98
    
    Appearance
    
    white solid powder
    
    Synonyms
    
    AT-7519, AT7519, AT 7519, AT-7519 free base
- Properties
  - InChI Key
    
    OVPNQJVDAFNBDN-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)
    
    Canonical SMILES
    
    C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl
- Reference Reading
  - 1.Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.
    
    Cihalova D1, Staud F, Ceckova M. Cancer Chemother Pharmacol. 2015 Jul;76(1):105-16. doi: 10.1007/s00280-015-2772-1. Epub 2015 May 19.
    
    PURPOSE: ATP-binding cassette (ABC) transporters play an important role in multidrug resistance (MDR) toward anticancer drugs. Here, we evaluated interactions of cyclin-dependent kinase inhibitors (CDKi) AT-7519, flavopiridol and SNS-032 with the following ABC transporters in vitro: P-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated protein 1 (ABCC1).
- Preparing Stock Solutions
  - ConcentrationVolumeMass 1 mg 5 mg 10 mg
    
    1 mM 2.6162 mL 13.0808 mL 26.1616 mL
    
    5 mM 0.5232 mL 2.6162 mL 5.2323 mL
    
    10 mM 0.2616 mL 1.3081 mL 2.6162 mL
    
    50 mM - - -

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.6162 mL	13.0808 mL	26.1616 mL
5 mM	0.5232 mL	2.6162 mL	5.2323 mL
10 mM	0.2616 mL	1.3081 mL	2.6162 mL
50 mM	-	-	-

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