Project Background
A biotechnology client was interested in a transcription-associated protein with strong disease relevance but limited suitability for conventional inhibitor development. The client wanted to explore whether a molecular glue strategy could create a differentiated discovery route, but lacked a clear ligase hypothesis, screening workflow, and mechanism validation plan.
Our Support
We began with a target feasibility and interaction-context review to identify potential induced-proximity opportunities and prioritize the most relevant ligase hypotheses. Based on this analysis, we designed a focused screening workflow that combined virtual prioritization, a compact screening set, and mechanism-informed hit triage. After the initial campaign, we shortlisted 18 primary hits and progressed 6 compounds into confirmatory studies. Through iterative chemistry analysis, interaction modeling, and biological validation, we identified 2 lead-like molecules that reproducibly enhanced the target-associated interaction signature and showed clear functional activity in cellular assays. Compared with the original screening hits, the top compound series delivered stronger consistency, better selectivity trends, and a more actionable optimization direction for the client.
Client Testimonial
BOC Sciences helped us turn a highly exploratory concept into a much more structured molecular glue discovery program. Their team provided practical guidance on screening logic, hit validation, and optimization priorities, which significantly improved our project clarity.
Project Background
A pharmaceutical discovery team aimed to build a ligase-centered molecular glue platform around a protein degradation concept but faced uncertainty in substrate recruitment logic, hit-finding strategy, and early mechanism confirmation. The client needed an external partner to support both technical exploration and efficient project execution.
Our Support
We first mapped the client’s ligase system, target class assumptions, and intended biological outcome, then established a phased discovery plan covering hypothesis generation, screening design, and validation criteria. We screened multiple chemistry directions and evaluated their ability to promote productive interaction signatures using a mechanism-focused assay cascade. Across the project, we assessed more than 40 compounds and identified 5 validated active series for deeper review. By integrating structure-guided interpretation, analog prioritization, and functional testing, we narrowed the project to 1 most promising chemistry family with improved reproducibility, clearer mechanism evidence, and better developability trends than the earlier hits. This gave the client a stronger basis for internal expansion of the program.
Client Testimonial
From project design to hit refinement, BOC Sciences provided systematic and responsive support throughout our molecular glue discovery effort. Their ability to connect biology, chemistry, and mechanism evaluation helped us make faster and more confident decisions.
Enables Compact and Efficient Degrader Design
