Linker Design and Optimization Services
As a leading service provider in drug discovery and research, BOC Sciences is fully qualified and committed to providing one-stop PROTAC® development, which has become a promising strategy in the field of small molecular drug discovery. With a comprehensive and advanced platform, we provide Linker Design and Optimization Services to customers around the world to meet new drug discovery goals.
Introduction of the Linker
The linker is responsible for linking two key domains of PROTAC: the domain that specifically binds to the target protein that needs to be degraded, and the domain that binds to the E3 ubiquitin ligase. To date, several types of connectors have been reported and used in the formation of PROTAC ternary complexes, such as PEG liner, alkyl liner and "click chemical" liner. It plays an important role in the effective ubiquitination and final degradation of target proteins.
Linker Design and Optimization Services
- From Molecular Design to Evaluation.
- The maximum interaction can be achieved by fine-tuning the distance between the two participating chaperones (target protein and E3 ligase) to optimize the linker length.
- The length of linker can range from 12 carbon to more than 20 carbon.
Our Advantages
- Advanced equipment and technique
- Experienced scientific team
- The advanced linker design and synthesis platform
- Highly reliable and reproducible result
- Data analysis, detailed report with results and discussion
- Quality one-stop service
References:
- Ciechanover, A. (2003). The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting.
- Churcher, I. (2017). Protac-induced protein degradation in drug discovery: breaking the rules or just making new ones? Journal of medicinal chemistry, 61(2), 444-452.
* PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
