PROTAC Activity Assay

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* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

As a leading service provider in the field of drug discovery and research, BOC Sciences has established an advanced one-stop Proteolysis Targeting Chimeric (Protac®) service platform. We offer technical services for Protac® activity assay. Our expert team has rich experience and professional technical knowledge about Protac® activity assay, and can carry out the activity detection according to the specific needs of different customers.

Introduction

Protac® is composed of 3 independent parts, and each part can be replaced or adjusted individually, so that there is a difference in activity between different Protac® compounds. For example, the change of linker length has a certain effect on the activity of Protac® to degrade the estrogen receptor. In addition, the peptide length of E3 ligase recognition motif and the binding site of the linker also changes the activity of Protac®. The activity of Protac® directly affects its potency and the degradation of the target protein, so it is necessary to perform Protac® activity assay during its development and screening process.

Protac<sup>®</sup> Activity Assay

Our Services for Protac® Activity Assay (include but not limited to the following):

Our Advantages

Workflow of Protac® Activity Assay

Protac<sup>®</sup> Activity Assay

References:

  1. Cyrus, K.; et al. Impact of linker length on the activity of Protacs. Molecular BioSystems. 2011, 7(2): 359-64.
  2. Toure, M.; Crews, C. M. Small-molecule Protacs: new approaches to protein degradation. Angewandte Chemie International Edition. 2016, 55(6): 1966-1973.
  3. Daniels, D.L.; et al. Monitoring and deciphering protein degradation pathways inside cells. Drug Discovery Today: Technologies. 2019, 31: 61-68.

* PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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