PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202693	N1-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N8-hydroxyoctanediamide	2233579-08-1	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 430.46 Molecular Formula: C21H26N4O6 Density: 1.385±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202694	N1-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N9-hydroxynonanediamide	2758388-36-0	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 444.49 Molecular Formula: C22H28N4O6 Density: 1.358±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202695	N1-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N10-hydroxydecanediamide	2758388-37-1	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 458.52 Molecular Formula: C23H30N4O6 Density: 1.333±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202696	N1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-N8-hydroxyoctanediamide	2758388-38-2	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 444.44 Molecular Formula: C21H24N4O7 Density: 1.446±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202697	6-(3-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ureido)-N-hydroxyhexanamide	2758388-47-3	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 431.45 Molecular Formula: C20H25N5O6 Density: 1.423±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202698	7-(3-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ureido)-N-hydroxyheptanamide	2758388-48-4	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 445.48 Molecular Formula: C21H27N5O6 Density: 1.393±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202699	9-(3-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ureido)-N-hydroxynonanamide	2758388-49-5	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 473.53 Molecular Formula: C23H31N5O6 Density: 1.342±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202700	6-(3-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)ureido)-N-hydroxyhexanamide	2758388-50-8	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 445.43 Molecular Formula: C20H23N5O7 Density: 1.486±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202701	N-(2-Aminophenyl)-4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzamide	2758388-53-1	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 484.51 Molecular Formula: C27H24N4O5 Boiling Point: 743.4±60.0°C at 760 Torr Density: 1.420±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202702	N-(2-Aminophenyl)-4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)benzamide	2758388-54-2	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 498.49 Molecular Formula: C27H22N4O6 Boiling Point: 725.6±60.0°C at 760 Torr Density: 1.476±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202703	4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)-N-hydroxybenzamide	2758388-57-5	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 409.40 Molecular Formula: C21H19N3O6 Density: 1.455±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202704	4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-N-hydroxybenzamide	2758388-58-6	CRBN	HDAC1 HDAC3 HDAC6	Inquiry
Molecular Weight: 423.38 Molecular Formula: C21H17N3O7 Density: 1.524±0.06 g/cm3 Description: It is an HDAC degrader with a CRBN E3 ligase ligand.
	BPL-202705	C004019	2417159-57-8	VHL	Tau	Inquiry
Molecular Weight: 1035.31 Molecular Formula: C49H70N12O9S2 Density: 1.300±0.06 g/cm3 Description: It is a small molecule PROTAC that selectively promotes tau clearance to improve cognitive functions in Alzheimer's like models.
	BPL-202706	(S)-2-Chloro-N-(4-(2-((2-(2-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)ethoxy)ethyl)amino)-2-oxoethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-N-(2-cyanoethyl)acetamide	2763548-62-3	FEM1B	BRD4	Inquiry
Molecular Weight: 806.78 Molecular Formula: C38H41Cl2N9O5S Density: 1.44±0.1 g/cm3 Description: It is a PROTAC linking EN106 to the BET bromodomain inhibitor JQ1, resulting in the degradation of BRD4.
	BPL-202707	(S)-2-Chloro-N-(4-(2-((5-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)pentyl)amino)-2-oxoethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-N-(2-cyanoethyl)acetamide	2709040-03-7	FEM1B	BRD4	Inquiry
Molecular Weight: 804.81 Molecular Formula: C39H43Cl2N9O4S Density: 1.41±0.1 g/cm3 Description: It is a PROTAC linking EN106 to the BET bromodomain inhibitor JQ1, resulting in the degradation of BRD4.
	BPL-202708	(S)-2-Chloro-N-(4-(14-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-N-(2-cyanoethyl)acetamide	2763548-65-6	FEM1B	BRD4	Inquiry
Molecular Weight: 850.83 Molecular Formula: C40H45Cl2N9O6S Density: 1.42±0.1 g/cm3 Description: It is a PROTAC linking EN106 to the BET bromodomain inhibitor JQ1, resulting in the degradation of BRD4.
	BPL-202709	(S)-2-Chloro-N-(4-(17-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-N-(2-cyanoethyl)acetamide	2763548-67-8	FEM1B	BRD4	Inquiry
Molecular Weight: 894.88 Molecular Formula: C42H49Cl2N9O7S Density: 1.40±0.1 g/cm3 Description: It is a PROTAC linking EN106 to the BET bromodomain inhibitor JQ1, resulting in the degradation of BRD4.
	BPL-202710	(S)-2-Chloro-N-(4-(20-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,19-dioxo-6,9,12,15-tetraoxa-3,18-diazaicosyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-N-(2-cyanoethyl)acetamide	2763548-69-0	FEM1B	BRD4	Inquiry
Molecular Weight: 938.94 Molecular Formula: C44H53Cl2N9O8S Density: 1.39±0.1 g/cm3 Description: It is a PROTAC linking EN106 to the BET bromodomain inhibitor JQ1, resulting in the degradation of BRD4.
	BPL-202711	N-(2-Chloro-6-methylphenyl)-2-((6-(4-(5-(2-(7-(2-chloro-N-(2-cyanoethyl)acetamido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)acetamido)pentyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide	2763548-75-8	FEM1B	BCR-ABL	Inquiry
Molecular Weight: 848.86 Molecular Formula: C40H47Cl2N11O4S Density: 1.366±0.06 g/cm3 Description: It is a PROTAC linking EN106 to the kinase inhibitor dasatinib, resulting in the degradation of BCR-ABL.
	BPL-202712	N-(2-Chloro-6-methylphenyl)-2-((6-(4-(1-(7-(2-chloro-N-(2-cyanoethyl)acetamido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide	2763548-77-0	FEM1B	BCR-ABL	Inquiry
Molecular Weight: 938.94 Molecular Formula: C43H53Cl2N11O7S Density: 1.361±0.06 g/cm3 Description: It is a PROTAC linking EN106 to the kinase inhibitor dasatinib, resulting in the degradation of BCR-ABL.