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Baricitinib - CAS 1187594-09-7

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Catalog Number	Size	Price	Stock	Quantity
BP-300179	1 g	$199	In stock

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Baricitinib is a selective and orally bioactive inhibitor of JAK1 and JAK2. It has been approved by FDA for the treatment of rheumatoid arthritis (RA).

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Molecular Formula

C16H17N7O2S

Molecular Weight

371.419

Baricitinib

- Specification
  - Related CAS
    
    1187595-84-1 (phosphate)
    
    Purity
    
    >98%
    
    Appearance
    
    White to Off-white Solid
    
    Application
    
    the treatment of rheumatoid arthritis (RA)
    
    Synonyms
    
    LY3009104; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; Olumiant
- Properties
  - Boiling Point
    
    707.2±70.0 °C at 760 mmHg
    
    Melting Point
    
    212-215°C
    
    Density
    
    1.6±0.1 g/cm3
    
    InChI Key
    
    XUZMWHLSFXCVMG-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
    
    Canonical SMILES
    
    CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
- Reference Reading
  - 1.Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate.
    Keystone EC1, Taylor PC2, Drescher E3, Schlichting DE4, Beattie SD4, Berclaz PY4, Lee CH4, Fidelus-Gort RK5, Luchi ME5, Rooney TP4, Macias WL4, Genovese MC6. Ann Rheum Dis. 2015 Feb;74(2):333-40. doi: 10.1136/annrheumdis-2014-206478. Epub 2014 Nov 27.
    OBJECTIVES: To investigate baricitinib (LY3009104, formerly INCB028050), a novel, oral inhibitor of JAK1/JAK2 in patients with moderate to severe rheumatoid arthritis (RA) despite treatment with methotrexate.
    2.Baricitinib in Patients with Refractory Rheumatoid Arthritis.
    Genovese MC1, Kremer J1, Zamani O1, Ludivico C1, Krogulec M1, Xie L1, Beattie SD1, Koch AE1, Cardillo TE1, Rooney TP1, Macias WL1, de Bono S1, Schlichting DE1, Smolen JS1. N Engl J Med. 2016 Mar 31;374(13):1243-52. doi: 10.1056/NEJMoa1507247.
    BACKGROUND: In phase 2 studies, baricitinib, an oral Janus kinase 1 and 2 inhibitor, reduced disease activity in patients with rheumatoid arthritis who had not previously received treatment with biologic disease-modifying antirheumatic drugs (DMARDs).
    3.Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib.
    Jabbari A1, Dai Z1, Xing L2, Cerise JE1, Ramot Y3, Berkun Y4, Sanchez GA5, Goldbach-Mansky R5, Christiano AM6, Clynes R7, Zlotogorski A3. EBioMedicine. 2015 Feb 26;2(4):351-5. doi: 10.1016/j.ebiom.2015.02.015. eCollection 2015.
    BACKGROUND: Alopecia areata (AA) is an autoimmune disease resulting in hair loss with devastating psychosocial consequences. Despite its high prevalence, there are no FDA-approved treatments for AA. Prior studies have identified a prominent interferon signature in AA, which signals through JAK molecules.
- Preparing Stock Solutions
  - ConcentrationVolumeMass 1 mg 5 mg 10 mg
    
    1 mM 2.6924 mL 13.4618 mL 26.9237 mL
    
    5 mM 0.5385 mL 2.6924 mL 5.3847 mL
    
    10 mM 0.2692 mL 1.3462 mL 2.6924 mL
    
    50 mM 0.0538 mL 0.2692 mL 0.5385 mL

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.6924 mL	13.4618 mL	26.9237 mL
5 mM	0.5385 mL	2.6924 mL	5.3847 mL
10 mM	0.2692 mL	1.3462 mL	2.6924 mL
50 mM	0.0538 mL	0.2692 mL	0.5385 mL

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