(+)-JQ-1 - CAS 1268524-70-4

(+)-JQ-1 is a potent and selective BET bromodomain inhibitor, IC50 values are 77 nM and 33 nM for inhibiting BRD4 (N-terminal) and BRD4 (C-terminal), respectively.

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Molecular Formula
C₂₃H₂₅ClN₄O₂S
Molecular Weight
456.99

(+)-JQ-1

    • Specification
      • Appearance
        White solid
        Synonyms
        JQ1
        Solubility
        In DMSO: ≥ 45 mg/mL (98.47 mM)
        * "≥" means soluble, but saturation unknown.
        Storage
        Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
        Shelf Life
        2 years
        Shipping
        Room temperature in continental US; may vary elsewhere.
    • Properties
      • Density
        1.33±0.1 g/cm3
        InChI Key
        DNVXATUJJDPFDM-KRWDZBQOSA-N
        InChI
        1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
        Canonical SMILES
        O=C(OC(C)(C)C)C[C@@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C
        Pub Chem ID
        46907787
    • Preparing Stock Solutions
      • ConcentrationVolumeMass1 mg5 mg10 mg
        1 mM2.19 mL10.94 mL21.88 mL
        5 mM0.44 mL2.19 mL4.38 mL
        10 mM0.22 mL1.09 mL2.19 mL
        50 mM0.04 mL0.22 mL0.44 mL
Bio Calculators
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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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