APLF (Aprataxin and PNK-like factor)

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APLF (Aprataxin and PNK-like factor) nuclease is involved in the repair of single-stranded and double-stranded DNA breaks. The DNA damage site was recruited by interacting with poly (ADP- ribose). The enzyme is a kind of post-translational modification synthesized briefly at the chromosome damage site, which can accelerate the repair of DNA strand breaks. The activities of purine-pan-pyrimidine nucleoside (AP) endonuclease and 3'-5' exonuclease were shown in vitro. Incisions can also be introduced when hydroxyuracil and other types of pyrimidine bases are destroyed. Together with PARP3, it can promote the chromatin retention of LIG4-XRCC4 complex and accelerate the DNA connection during the nonhomologous end joining (NHEJ).

Cat.No.Product NameSourceSpeciesTagMolecular Weight
BP-801004Recombinant Human APLFMammalian CellsHumanHis
BP-801005Recombinant Human APLF protein, DDK-taggedInsect cellsHumanDDK
BP-801006Recombinant Human APLF protein, MYC/DDK-taggedHEK293HumanMYC/DDK
BP-801007Recombinant Mouse APLF ProteinMammalian CellsMouseHis
BP-801008Recombinant Bovine APLF, His-taggedE. Coli or YeastBovineHis
BP-801009Recombinant Chicken APLFMammalian CellsChickenHis
BP-801010Recombinant Human APLF protein, GST-taggedWheat GermHumanGST
BP-801011Recombinant Human APLF, GST-taggedE.coliHumanGST

* PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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