ATG16L1 (Autophagy related 16 like 1)

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ATG16L1 (Autophagy related 16 like 1) is a protein encoded by ATG16L1 gene. The protein encoded by this gene is part of a large protein complex necessary for autophagy, which is the main process in which intracellular components are located to lysosomes for degradation. ATG16L1 plays an important role in autophagy: it interacts with ATG12-ATG5, mediates the binding of phosphatidylethanolamine (PE) to LC3, and produces a membrane-bound LC3 activation form called LC3-II. So as to control the elongation of neonatal autophagy membrane. Diseases associated with ATG16L1 include inflammatory bowel disease 10 and Crohn's disease. Related pathways include Macroautophagy and Shigellosis.

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