BDNF(Brain-derived neurotrophic factor)

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BDNF (Brain-derived neurotrophic factor) is a neurotrophic protein first found in pig brain by Barde et al in 1982. Brain-derived neurotrophic factor and its receptors are widely expressed in the nervous system. BDNF molecular monomer is a secretory mature peptide composed of 119 amino acid residues. BDNF is distributed in a wide range of regions, such as central nervous system, peripheral nervous system, endocrine system, bone and cartilage, but it is mainly expressed in the central nervous system, especially in hippocampus and cortex. In the brain, the BDNF protein is active at the junctions between nerve cells (synapses), where intercellular communication occurs. Synapses can change over time and adapt to experience, which is called synaptic plasticity. BDNF proteins help regulate synaptic plasticity, which is important for learning and memory.

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