CDKL5 (Cyclin-dependent kinase-like 5)

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CDKL5 (Cyclin-dependent kinase-like 5) is a large protein with serine/threonine domain and has high homology with mitogen-activated protein kinase (MAPK) and cyclin. Because the expression of CDKL5 in the brain is particularly strong and located in the cytoplasm and nucleus, it is speculated that CDKL5 is related to several neural functions. CDKL5 is thought to be related to dendritic structure, dendritic spine morphology and neuronal cell death. CDKL5 Deficiency Disorder (CDD) is a rare disease caused by mutations in the CDKL5 gene. Almost all the CDKL5 mutations that cause the disease appear from scratch and lead to the loss of CDKL5 gene function. Mutations or deletions of CDKL5, encode cyclin-dependent kinase-like 5, leading to unique epileptic encephalopathy in the first 3 months of life and seizures, often close to the end of the neonatal period.

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