COMT (Catechol-O-methyltransferase)

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COMT (Catechol-O-methyltransferase) is an enzyme that catalyzes the methyl transfer of S-Adenosylmethionine to the 3-hydroxyl group of the benzene ring of catechins or catecholamines, thereby degrading various drugs containing catecholamines, catechol estrogens, and catechol structures. In humans, the catechol-O-methyltransferase protein is encoded by the COMT gene. Levodopa is the precursor of catecholamine and an important substrate of COMT. COMT inhibitors such as entacapone can save levodopa from COMT and prolong the effect of levodopa. In the brain, COMT-dependent dopamine degradation is particularly important in brain regions with low expression of presynaptic dopamine transporter (DAT). COMT inhibitors are used to treat Parkinson's disease.

Cat.No.Product NameSourceSpeciesTagMolecular Weight
BP-801113Recombinant Human Catechol-O-MethyltransferaseHuman
BP-801114Recombinant Human Catechol-O-methyltransferase, His-tagged
BP-801115Recombinant Mouse COMT protein, His-taggedE. coliMouseHis
BP-801116Recombinant Rat COMT protein, His-taggedE. coliRatHis
BP-801117Recombinant Human COMT Protein, GST-taggedWheat GermHumanGST
BP-801118Recombinant Human COMT Protein, His-taggedE. coliHumanHis
BP-801119Recombinant Human COMT, His-taggedE. coli
BP-801120Recombinant Human COMTE. coli
BP-801121Recombinant Mouse COMT ProteinMammalian CellsMouseHis
BP-801122Recombinant Rhesus monkey COMT Protein, His-taggedMammalian CellsRhesus monkeyHis

* PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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