COMT (Catechol-O-methyltransferase)

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COMT (Catechol-O-methyltransferase) is an enzyme that catalyzes the methyl transfer of S-Adenosylmethionine to the 3-hydroxyl group of the benzene ring of catechins or catecholamines, thereby degrading various drugs containing catecholamines, catechol estrogens, and catechol structures. In humans, the catechol-O-methyltransferase protein is encoded by the COMT gene. Levodopa is the precursor of catecholamine and an important substrate of COMT. COMT inhibitors such as entacapone can save levodopa from COMT and prolong the effect of levodopa. In the brain, COMT-dependent dopamine degradation is particularly important in brain regions with low expression of presynaptic dopamine transporter (DAT). COMT inhibitors are used to treat Parkinson's disease.

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