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COMT (Catechol-O-methyltransferase) is an enzyme that catalyzes the methyl transfer of S-Adenosylmethionine to the 3-hydroxyl group of the benzene ring of catechins or catecholamines, thereby degrading various drugs containing catecholamines, catechol estrogens, and catechol structures. In humans, the catechol-O-methyltransferase protein is encoded by the COMT gene. Levodopa is the precursor of catecholamine and an important substrate of COMT. COMT inhibitors such as entacapone can save levodopa from COMT and prolong the effect of levodopa. In the brain, COMT-dependent dopamine degradation is particularly important in brain regions with low expression of presynaptic dopamine transporter (DAT). COMT inhibitors are used to treat Parkinson's disease.
|Cat.No.||Product Name||Source||Species||Tag||Molecular Weight|
|BP-801113||Recombinant Human Catechol-O-Methyltransferase||Human|
|BP-801114||Recombinant Human Catechol-O-methyltransferase, His-tagged|
|BP-801115||Recombinant Mouse COMT protein, His-tagged||E. coli||Mouse||His|
|BP-801116||Recombinant Rat COMT protein, His-tagged||E. coli||Rat||His|
|BP-801117||Recombinant Human COMT Protein, GST-tagged||Wheat Germ||Human||GST|
|BP-801118||Recombinant Human COMT Protein, His-tagged||E. coli||Human||His|
|BP-801119||Recombinant Human COMT, His-tagged||E. coli|
|BP-801120||Recombinant Human COMT||E. coli|
|BP-801121||Recombinant Mouse COMT Protein||Mammalian Cells||Mouse||His|
|BP-801122||Recombinant Rhesus monkey COMT Protein, His-tagged||Mammalian Cells||Rhesus monkey||His|
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