HMGN1 (high mobility group nucleosome binding domain 1)

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HMGN1 (high mobility group nucleosome binding domain 1), also known as HMG14, is a ubiquitous vertebrate nuclear protein, which can specifically bind to nucleosome core granules (a component of chromatin fibers). The expression of HMGN1 is closely related to cell differentiation. HMGN1 is ubiquitous and highly expressed in all embryonic tissues. During mouse embryogenesis, the expression is down-regulated throughout the embryo, except for active differentiation in stereotyped but continuously renewed cell types. The expression of HMGN1 is also down-regulated during myogenesis, erythropoiesis and osteogenesis. Overexpression of HMGN1 inhibits myotube formation in C2C12 myoblasts and chondrocyte differentiation in primary limb bud mesenchymal cells, suggesting its role in blocking cell differentiation. Diseases associated with HMGN1 include cocaine syndrome and Down syndrome.

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