LGI1 (Leucine Rich Glioma Inactivated 1)

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LGI1 (Leucine Rich Glioma Inactivated 1) is a protein that encodes the LGI1 gene in humans. It may be a metastasis inhibitor. The protein contains a hydrophobic fragment that represents a hypothetical transmembrane domain with an N-terminal outside the cell. It also contains repetitive sequences rich in leucine and conserved flanking sequences rich in cysteine. The gene is mainly expressed in nerve tissue and decreased in low-grade brain tumors and significantly decreased or not expressed in malignant gliomas. Diseases associated with LGI1 include epilepsy, familial temporal lobe disease, and autosomal dominant epilepsy with auditory features. LGI1 has been shown to be the main target of human autoantibodies, which can immunoprecipitate voltage-gated potassium channel complexes from mammalian brain tissue.

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