NPC2 (Niemann-Pick Disease Type C2 Protein)

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NPC2 (Niemann-Pick Disease Type C2 Protein) is a lysosomal lumen protein that cooperates with NPC1 to mediate the efflux of LDL-derived cholesterol from the lysosome and plays a role in regulating cholesterol through the endosomal / lysosomal late system. The secretory form of NCP2 regulates bile cholesterol secretion by stimulating cholesterol transport mediated by ABCG5/ABCG8. The mutation of NCP2 is associated with Niemann-Pick Disease, Type C2 and Frontal Lobe Atrophy.

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