PINK1 (PTEN-induced kinase 1)

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As a mitochondrial membrane protein, PINK1 (PTEN-induced kinase 1) has protein kinase activity. PINK1 is involved in many metabolic processes. PINK1 is located in the outer membrane of mitochondria and can regulate cell function by phosphorylating a variety of proteins in cells. At the same time, PINK1 is closely related to mitochondria, and can regulate the morphology, function and autophagy of mitochondria through multiple pathways, but the specific regulation mode has not been fully elucidated. Because PINK1 is widely expressed, especially in high energy consumption tissues, and has a variety of biological activities, it may be involved in the occurrence, development and regulation of many diseases. For example, mutations in the serine/threonine kinase domain have been found in many patients with Parkinson’s disease, in which PINK1 can not protect against stress-induced mitochondrial dysfunction and apoptosis.

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