PON3 (Paraoxonase 3)

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PON3 (Paraoxonase 3) is a member of the paraoxonase family and is located in the cluster on chromosome 7 along with the other two family members. PON3 is mainly expressed in liver and kidney and binds to HDL in circulation. They inhibit lipid peroxidation of LDL and HDL particles in plasma. Human PON3 contains 354 amino acids and is a glycoprotein of about 40 kDa with calcium-dependent esterase activity. 98% of human PON3 binds to HDL in serum, and the concentration of PON3 in serum is much lower than that of PON1, which is about 50% of the concentration of PON1. Studies have shown that PON3 can prevent the oxidative stress of cells and tissues by reducing reactive oxygen species. It can inhibit the oxidation of LDL and enhance the antioxidation and cholesterol transport ability of HDL. It not only plays a good protective role in the occurrence and development of atherosclerosis, but also plays a favorable role in obesity, inflammatory bowel disease, liver injury and many other disease states.

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