QPRT (quinolinate phosphoribosyltransferase)

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Quinolinate is an intermediate in the ab initio synthesis of NAD from tryptophan and acts as an effective endogenous excitotoxin by over-stimulating the receptor of N-methyl D-aspartate (NMDA) in neurons. It has been speculated that the increase of quinolinate level in human brain is related to the pathogenesis of neurodegenerative diseases. Mammalian quinoline ester phosphoribosyltransferase (QPRTase) is a key enzyme in the catabolism of quinoline esters. Quinolinate is the most effective endogenous toxin in neurons. Increased levels of quinolinic acid in the brain are associated with the pathogenesis of neurodegenerative diseases such as epilepsy, Alzheimer's disease and Huntington's disease.

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