As a leading service provider in drug discovery and research, BOC Sciences is fully capable and committed to providing one-stop proteolysis targeting molecular drug discovery based on chimeric (PROTAC®). BOC Sciences offers a wide range of solution-state NMR services, either independently or as part of a multidisciplinary team that includes our drug support and mass spectrometry teams.
Introduction
In the process of research and development of modern drugs, new methods and technologies that can detect the chemical composition and structure of drugs and their interaction with biomolecules have always been one of the most concerned scientific issues. Spectral analysis (including infrared, ultraviolet and nuclear magnetic resonance) is the most commonly used analysis method. Among them, nuclear magnetic resonance spectroscopy can obtain the parameters that reflect the nuclear-related properties by detecting the transition law of the nuclei that make up the molecules of organic compounds under the influence of the surrounding chemical environment. These parameters contain detailed information about the molecular structure and intermolecular interaction of organic compounds. Nuclear magnetic resonance (NMR) can provide detailed structures of peptides and macrocycles, that is molecules that generally do not crystallize. These detailed structures guide the design of PROTAC that are more potent, more stable, and/or more bioavailable.
Application
Nuclear magnetic resonance spectroscopy can provide rich information about molecular composition, three-dimensional structure of atomic resolution, interaction and dynamic process in a variety of complex conditions, such as liquid, solid, gaseous, and even in the biological in-situ environment, especially the interaction information between drug molecules and biological macromolecules, which is very important in drug research and development. Therefore, nuclear magnetic resonance spectroscopy plays a more and more important role in drug research and development, and it is more and more widely used in the field of drug research and development in recent years.
Our Services
- The validation of the filter hit; the definition of the binding location.
- The fragment library was screened by NMR to obtain the (TPD) ligands of the leader and targeted protein degradation products.
- Complete and detailed structures of proteins, protein-ligand complexes, peptides, macrocycles, oligonucleotides and antisense molecules.
- Advanced nuclear magnetic resonance methods are used to determine and verify the structure of small molecules.
Our Advantages
- Our NMR variable-temperature, tunable broadband probe can be set to virtually any nucleus
- High-quality data on smaller amounts of material in less time
- One-stop service from scratch to full development
- Experienced scientists and technicians
- Advanced structural analysis platform
- Data analysis, detailed report with results and discussion
- The molecules can be fully characterized by one-dimensional and two-dimensional NMR experiments
* PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
