1,3-Dibromo-5,5-dimethylhydantoin
CAS No.: 77-48-5
Cat No.: BP-501497
Purity: 97+%
4.5 
1,3-Dibromo-5,5-dimethylhydantoin is a brominating and linker-modifying reagent that can support PROTAC linker chemistry by enabling preparation of brominated intermediates or electrophilic attachment handles. Its hydantoin-based structure serves as a bromine-transfer source for functionalizing organic scaffolds that may later be converted into linker fragments, leaving-group-bearing intermediates, or ligand attachment points. In targeted degradation research, this product is useful in synthetic route development where controlled bromination is required before substitution, coupling, or further linker elaboration. Its value lies in expanding linker precursor functionalization strategies rather than directly determining degrader biological performance.
Structure of 77-48-5
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1,3-Dibromo-5,5-dimethylhydantoin is a bromination reagent used in PROTAC linker precursor preparation rather than a spacer linker itself. It is useful for installing brominated handles that can later undergo substitution, coupling, or further functional-group conversion. The structure and reactivity are described below.
Structure: The reagent contains a dimethylhydantoin imide core bearing electrophilic nitrogen-bromine bonds. The cyclic imide stabilizes bromine-transfer reactivity and provides a defined, solid brominating reagent scaffold.
Reactivity: It can deliver electrophilic bromine to suitable alkene, aromatic, heteroaromatic, or activated aliphatic substrates depending on conditions. In PROTAC linker workflows, it is most appropriate for preparing brominated intermediates that subsequently participate in nucleophilic substitution or cross-coupling. Compatibility with oxidation-sensitive ligands should be assessed carefully.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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