BETd-260 - CAS 2093388-62-4

BETd-260, also known as ZBC260, is a potent and selective BET inhibitor or BET degrader. BETd-260 effectively degrades BRD4 protein at concentrations as low as 30 pM in the RS4;11 leukemia cell line, achieves an IC50 value of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors. BETd-260 is a highly potent and efficacious BET degrader.

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Molecular Formula
C43H46N10O6
Molecular Weight
798.89

BETd-260

    • Specification
      • Synonyms
        ZBC260; ZBC 260; ZBC-260; BETd-260; BETd 260; BETd260. 4-[(5-cyclopropyl-2-ethylpyrazol-3-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide
        Solubility
        H2O : < 0.1 mg/mL (insoluble); DMSO : 25 mg/mL (31.29 mM; Need ultrasonic)
        Storage
        Powder
        -20°C
        3 years


        In solvent
        -80°C
        6 months



        -20°C
        1 month
        Shipping
        Room temperature in continental US; may vary elsewhere
    • Properties
      • InChI Key
        UZXANFBIRSYHGO-UHFFFAOYSA-N
        InChI
        InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)
        Canonical SMILES
        CCN1C(=CC(=N1)C2CC2)NC3=NC(=NC4=C3C5=CC(=C(C=C5N4)C6=C(ON=C6C)C)OC)C(=O)NCCCCCC7=C8CN(C(=O)C8=CC=C7)C9CCC(=O)NC9=O
Bio Calculators
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L

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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