HDAC6 degrader 9c - CAS 2235382-05-3

It is a bifunctional PROTAC molecule that can selectively degrade HDAC6 by conjugating a non-selective HDAC inhibitor with an E3 ubiquitin ligase ligand.

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Molecular Formula
Molecular Weight

HDAC6 degrader 9c

    • Specification
      • Purity
        Soluble in DMSO
        Solid Powder
        Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
        IUPAC Name
        dHDAC6 9c; (E)-8-(2-(4-(2-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)benzylidene)hydrazineyl)-N-hydroxy-8-oxooctanamide; 8-[(2E)-2-{4-[2-(2-{2-[4-({[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethoxy)ethoxy]benzylidene}hydrazino]-N-hydroxy-8-oxooctanamide; Octanoic acid, 8-(hydroxyamino)-8-oxo-, 2-[(1E)-[4-[2-[2-[2-[4-[[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]methylene]hydrazide; 8-(Hydroxyamino)-8-oxooctanoic acid (2E)-2-[[4-[2-[2-[2-[4-[[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]methylene]hydrazide
    • Properties
      • Density
        1.44±0.1 g/cm3
        InChI Key
        Canonical SMILES
    • Reference Reading
      • 1. Development of the first small molecule histone deacetylase 6 (HDAC6) degraders.
        Yang, K., Song, Y., Xie, H., Wu, H., Wu, Y.T., Leisten, E.D. and Tang, W., 2018. Bioorganic & medicinal chemistry letters, 28(14), pp.2493-2497.
        Histone deacetylases (HDACs) decrease the acetylation level of histones and other non-histone proteins. Over expression of HDACs have been observed in cancers and other diseases. Targeted protein degradation by "hijacking" the natural ubiquitin-proteasome-system (UPS) recently emerged as a novel technology to "knock-out" endogenous disease-causing proteins. We applied this strategy to the development of the first small molecule degraders for zinc-dependent HDACs by conjugating non-selective HDAC inhibitors with E3 ubiquitin ligase ligands. Through cell-based assays, we discovered novel bifunctional molecules (dHDAC6) that could selectively degrade HDAC6. Further mechanistic studies indicated that HDAC6 was selectively removed by the UPS.
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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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