(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Target: Targets von Hippel-Lindau ligand module for PROTAC construction for experimental targeted protein degradation studies.

Binding Site: Binds the VHL hydroxyproline-binding pocket used as an E3 ligase handle to support productive ternary complex formation.

Mechanism of Action: (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a modular building block for PROTAC and targeted protein degradation research. Rather than defining a single protein-of-interest, it provides an E3 ligase recruiting or conjugation element that can be linked to a target ligand through an optimized spacer. Systematic variation of linker length, exit vector, and attachment chemistry can tune ternary-complex geometry, ubiquitination efficiency, and degradation selectivity. The compound is useful for assembling comparator degraders, negative controls, or structure-activity series that dissect how E3 engagement influences cellular target depletion.

• PROTAC-Mediated Protein Degradation: (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is utilized in research to induce the selective degradation of target proteins via the ubiquitin-proteasome system. This compound facilitates the recruitment of E3 ligases to proteins of interest, enabling their ubiquitination and subsequent proteasomal degradation.

• Targeted Degradation in Cancer Research: This PROTAC molecule is pivotal in cancer research, allowing scientists to degrade oncogenic proteins that drive tumorigenesis. By specifically targeting and degrading these proteins, researchers can investigate new therapeutic strategies and understand cancer cell biology more deeply.

• Investigating Protein Function: Researchers employ (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine to study the role of specific proteins in cellular pathways. By degrading a target protein, scientists can observe resultant phenotypic changes, providing insights into protein function and signaling pathways.

• Drug Discovery and Development: This PROTAC compound aids in the discovery of novel drug candidates by enabling the degradation of disease-relevant proteins. It serves as a tool for validating potential drug targets and understanding the biochemical pathways involved in various diseases.