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ICG-Sulfo-OSu sodium - CAS 190714-28-4

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ICG-Sulfo-OSu sodium is a polyethylene glycol (PEG)-based PROTAC linker. ICG-Sulfo-OSu sodium can be used in the synthesis of a series of PROTACs.

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Molecular Formula

C₄₉H₅₂N₃NaO₁₀S₂

Molecular Weight

930.07

ICG-Sulfo-OSu sodium

- Specification
  - Storage
    
    Please store the product under the recommended conditions in the Certificate of Analysis.
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    sodium;1-[6-[2-[7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-2-ylidene]hepta-1,3,5-trienyl]-1,1-dimethylbenzo[e]indol-3-ium-3-yl]hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate
- Properties
  - InChI Key
    
    PUIWPNXPCPENEL-UHFFFAOYSA-M
    
    InChI
    
    InChI=1S/C49H53N3O10S2.Na/c1-48(2)41(23-9-6-5-7-10-24-42-49(3,4)46-37-22-15-13-20-35(37)27-29-39(46)51(42)31-17-18-32-63(56,57)58)50(38-28-26-34-19-12-14-21-36(34)45(38)48)30-16-8-11-25-44(54)62-52-43(53)33-40(47(52)55)64(59,60)61;/h5-7,9-10,12-15,19-24,26-29,40H,8,11,16-18,25,30-33H2,1-4H3,(H-,56,57,58,59,60,61);/q;+1/p-1
    
    Canonical SMILES
    
    CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCCC(=O)ON4C(=O)CC(C4=O)S(=O)(=O)[O-])C=CC=CC=CC=C5C(C6=C(N5CCCCS(=O)(=O)[O-])C=CC7=CC=CC=C76)(C)C)C.[Na+]
- Reference Reading
  - 1. Development of agents for reinforcement of fluorescence on near-infrared ray excitation for immunohistological staining
    
    S Ito, N Muguruma, S Hayashi, S Taoka, T Bando, K Inayama, M Sogabe, T Okahisa, S Okamura, H Shibata, T Irimura, K Takesako, S Shibamura Bioorg Med Chem. 1998 May;6(5):613-8. doi: 10.1016/s0968-0896(98)00023-6.
    
    Fluorescence intensity of indocyanine green (ICG) derivative (ICG-sulfo-OSu) was too low for its use to detect microlesions. Therefore, we examined the effects of reinforcement agents on ICG-sulfo-OSu labeled antibodies. Solutions of distearoylphosphatic acid sodium salt (DSPA) and octylglucoside (OG) in physiological phosphate buffered saline (PBS) were found to increase the intensity of fluorescence of ICG-sulfo-OSu labeled antibodies, with shift in the fluorescence peak wavelength from 804 to 821 nm.

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