1. Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial
Meletios A Dimopoulos, Evangelos Terpos, Mario Boccadoro, et al. Clinical TrialLancet Oncol. 2021 Jun;22(6):801-812.doi: 10.1016/S1470-2045(21)00128-5.
Background:In a phase 1b study, intravenous daratumumab plus pomalidomide and dexamethasone induced a very good partial response or better rate of 42% and was well tolerated in patients with heavily pretreated multiple myeloma. We aimed to evaluate whether daratumumab plus pomalidomide and dexamethasone would improve progression-free survival versus pomalidomide and dexamethasone alone in patients with previously treated multiple myeloma.
2. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study
Michel Attal, Paul G Richardson, S Vincent Rajkumar, et al. Clinical TrialLancet. 2019 Dec 7;394(10214):2096-2107.doi: 10.1016/S0140-6736(19)32556-5.Epub 2019 Nov 14.
Background:Isatuximab is a monoclonal antibody that binds a specific epitope on the human CD38 receptor and has antitumour activity via multiple mechanisms of action. In a previous phase 1b study, around 65% of patients with relapsed and refractory multiple myeloma achieved an overall response with a combination of isatuximab with pomalidomide and low-dose dexamethasone. The aim of this study was to determine the progression-free survival benefit of isatuximab plus pomalidomide and dexamethasone compared with pomalidomide and dexamethasone in patients with relapsed and refractory multiple myeloma.
3. Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma
Meletios A Dimopoulos, Dominik Dytfeld, Sebastian Grosicki, Philippe Moreau, Naoki Takezako, Mitsuo Hori, Xavier Leleu, Richard LeBlanc, Kenshi Suzuki, Marc S Raab, Paul G Richardson, Mihaela Popa McKiver, Ying-Ming Jou, Suresh G Shelat, Michael Robbins, Brian Rafferty, Jesús San-Miguel Clinical TrialN Engl J Med. 2018 Nov 8;379(19):1811-1822.doi: 10.1056/NEJMoa1805762.
Background:The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor.
