Name: Schisandrin C
Brand: BOC Sciences
Price: 199 USD
Availability: MadeToOrder

Purity

>98%

Solubility

<strong>DMF</strong>: 30 mg/ml,DMSO: 30 mg/ml

Appearance

Solid

Application

anti-neuroinflammatory

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

IUPACName

3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.02,10.04,8.017,21]docosa-1(22),2,4(8),9,15,17(21)-hexaene

Synonyms

<strong>Cycloocta[1,2-f</strong>:3,4-f']bis[1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, (6R,7S,13aS)-; Cycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, stereoisomer; (6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole; Wuweizisu C; Schizandrin C; (-)-Wuweizisu C; (S)-(-)-Schisandrin C; (-)-Schisandrin C

InChI Key

HTBWBWWADZJXID-UHFFFAOYSA-N

InChI

InChI=1S/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3

SMILES

O(C)C1=C2C3=C(OC)C4=C(C=C3CC(C)C(C)CC2=CC5=C1OCO5)OCO4

Mechanism

E3 Ligase: Schisandrin C does not function as a classical molecular glue that directly recruits E3 ligases such as CRBN, VHL, IAP, or MDM2. Instead, it can modulate cellular stress and signaling pathways that indirectly influence the activity of ubiquitin ligases and protein turnover.

Target Protein: The compound primarily interacts with proteins involved in oxidative stress responses and metabolic regulation, including key regulators of the Nrf2/Keap1 and related signaling pathways. These interactions can alter the stability of downstream proteins without direct substrate recruitment.

Degradation Mechanism: Schisandrin C affects protein turnover indirectly by modulating signaling networks that control ubiquitin-proteasome–mediated degradation. Proteins influenced by these pathways may be selectively processed by the 26S proteasome, while lysosomal degradation remains largely unaffected.

Applications

• Molecular Glue Mechanism Exploration: Schisandrin C serves as a valuable research tool for studying the molecular glue mechanism, facilitating the stabilization of protein-protein interactions. This application is crucial for elucidating the pathways through which molecular glues modulate protein dynamics, providing insights into the design of novel therapeutic strategies.

• Targeted Protein Degradation Studies: Utilize Schisandrin C to investigate its role in targeted protein degradation. By promoting the selective degradation of specific proteins, this compound aids researchers in understanding the intricacies of protein homeostasis and the potential for developing innovative treatments for protein-misfolding diseases.

• Enhancing E3 Ligase Recruitment: Schisandrin C can be employed to enhance E3 ligase recruitment in targeted degradation research. This application is instrumental in dissecting the molecular interactions that drive ubiquitin-proteasome pathway activation, offering a deeper understanding of cellular protein regulation mechanisms.

• Protein Interaction Modulation: Investigate the modulation of protein interactions using Schisandrin C as a molecular glue. This application direction supports research into the alteration of protein networks, providing a foundation for the development of strategies aimed at correcting aberrant protein interactions in various diseases.

1.[Study on main pharmacodynamic effects for Schisandra lignans based upon network pharmacology].

Qiu HT, Zhao XP, Li Z, Wang LL, Wang Y. Zhongguo Zhong Yao Za Zhi. 2015 Feb;40(3):522-7.

In this study, we focused on the study of pharmacodynamic effects for 6 major bioactive lignans of Schisandra chinensis, namely deoxyschizandrin, schisandrin B, schisandrin C, schisandrin, schizandrol B and schisantherin A. A compound-gene-pathway network, which contained 124 related genes and 88 pathways, was constructed by collecting drug genes through mining relevant literatures and network pharmacology analysis. Based on the network analysis, 32 pathways and 80 related genes were associated with inflammation, which implied that anti-inflammatory might be the major pharmacodynamic effects of these compounds. All lignans except schizandrol B reduced LPS-induced NO production in RAW264.7 cells, which validated the anti-inflammatory hypothesis generated from network analysis. Furthermore, we investigated the effects of deoxyschizandrin, schisandrin C, schisandrin and schisantherin A on the secretion of inflammatory cytokines TNF-α, IL-1β, IL-6, PGE2 and protein expressions of iNOS, COX-2.

2.Smashing Tissue Extraction of Five Lignans From the Fruit of Schisandra chinensis.

Cheng Z1, Song H2, Yang Y3, Zhou H1, Liu Y1, Liu Z1. J Chromatogr Sci. 2016 Feb;54(2):246-56. doi: 10.1093/chromsci/bmv116. Epub 2015 Aug 8.

Schisandra chinensis is one of the most famous herbal medicines in China, Korea and Japan. It has been widely used as a tonic, sedative, anti-aging and astringent agent. Lignans are one of its main bioactive components. The classical methods for extracting lignans, however, were tedious and energy-consuming. With the aim to develop an effective extraction method of lignans, the smashing tissue extraction (STE) technique was adopted and optimized in this study. Extraction conditions of STE have been optimized by the response surface methodology based on the Box-Behnken design. Results showed that 75% aqueous ethanol was the optimal extraction solvent, and the other optimal conditions were as follows: extraction voltage of 180 V, extraction time of 1 min, solid-liquid ratio of 1 : 19 and sample particle size of 120 mesh. Under these optimized conditions, the total content of the five lignans (Schisandrol A, Schisantherin A, Deoxyschisandrin, Schisandrin B and Schisandrin C) in S.

3.[Quality characteristic comparison of Schisandrae Chinensis Fructus from different place].

Zhou YF, Wang JB, Zhang DK, Tan P, Zhang HZ, Li BC, Xiao XH. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3152-7.

The contents of schisandrol A, schisandrol B, schisantherin A, schisandrin A , schisandrin B, schisandrin C in Schisandrae Chinensis Fructus (SCF) were determined simultaneously by HPLC. Collect 100-seed weight, color, pulp content, longitude and latitude of SCF of different batches were collected. SIMCA-P and SPSS were applied to make PLS-DA analysis of 24 batches of SCF and correlation analysis of relevant parameters. According to the 13 parameters, SCF from three different places of origin could be distinguished effectively. It was found that the content of chemical component of SCF increased with latitude and longitude first, and then decrease. The results provide some theoretical basis for study of SCF genuineness and traditional method of identifying just from experience.

4.[Study on chemical constituents from Schisandra chinensis stem].

Zheng LS, Du SS, Cai Q. Zhong Yao Cai. 2014 Oct;37(10):1803-6.

OBJECTIVE: To separate and identify the chemical constituents from the stem of Schisandra chinensis.

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.6013 mL	13.0066 mL	26.0132 mL
5 mM	0.5203 mL	2.6013 mL	5.2026 mL
10 mM	0.2601 mL	1.3007 mL	2.6013 mL
50 mM	0.0520 mL	0.2601 mL	0.5203 mL

HPLC

Dear Sirs, I would like to know how schisandrin C exerts anti-neuroinflammatory effects?

My pleasure! schisandrin C has a dibenzo cyclootadiene skeleton, which exerts anti-neuroinflammatory effects by upregulating phase II detoxifying and antioxidant enzymes in microglia.

13/3/2016

Hello, Can you tell me the mechanism of schisandrin C-mediated anti-inflammatory activity?

Yeah! schisandrin C-mediated anti-inflammatory activity is correlated with the inhibition of pro-inflammatory cytokine expression through blocking of NF-κB translocation followed by the inhibition of the p38 and stress-activated protein kinase/Jun N-terminal kinase (SAPK/JNK) pathway.

6/9/2018

Dear team, How does schisandrin C induce the upregulation of interferon β (IFN β) and ISGs expression? Thank you.

Good morning! schisandrin C promotes cGAS-STING signaling pathway activation by facilitating the interaction between TBK1 and STING, which induces the upregulation of interferon β (IFN β) and ISGs expression.

9/1/2019

promoted the expression of autophagy and mitochondrial biogenesis molecules

Schisandrin C promoted the expression of autophagy and mitochondrial biogenesis molecules. Very useful for our study!

12/11/2016

increased the mitochondrial activity against oxidative stress

It worked as expected. The effect of schisandrin C increased the mitochondrial activity against oxidative stress.

17/12/2016

inhibited inflammatory molecules with enhancing anti-oxidant activity

In our experiment, schisandrin C effectively inhibited inflammatory molecules with enhancing anti-oxidant activity and reducing reactive oxygen species (ROS) even in the presence of H2O2.

25/11/2020

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂