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Thalidomide-linker 2

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Thalidomide-linker 2 is a crosslinker−E3 ligase ligand conjugate composed of a cereblon-recuiting ligand thalidomide and a PEGylated crosslinker. It has been used as a degrader building block in PROTAC for targeted protein degradation.

* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

Molecular Formula
C25H34N4O10.HCl
Molecular Weight
587.02

Thalidomide-linker 2

    • Specification
      • Purity
        ≥98%
        Shelf Life
        2 years
        Storage
        -20°C
        Synonyms
        N-(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
    • Properties
      • InChI Key
        YHQOQBFOLKFJJN-UHFFFAOYSA-N
        InChI
        InChI=1S/C25H34N4O10.ClH/c26-6-8-35-10-12-37-14-15-38-13-11-36-9-7-27-21(31)16-39-19-3-1-2-17-22(19)25(34)29(24(17)33)18-4-5-20(30)28-23(18)32;/h1-3,18H,4-16,26H2,(H,27,31)(H,28,30,32);1H
        Canonical SMILES
        C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCOCCN.Cl
    • Reference Reading
      • 1. 2'-O-[2-(amino)-2-oxoethyl] oligonucleotides
        Thazha P Prakash, Andrew M Kawasaki, Elena A Lesnik, Stephen R Owens, Muthiah Manoharan Org Lett. 2003 Feb 20;5(4):403-6.doi: 10.1021/ol027131k.
        [structure: see text] Oligonucleotides with novel modifications, 2'-O-[2-(amino)-2-oxoethyl] (2'-O-NAc), 2'-O-[2-(methylamino)-2-oxoethyl] (2'-O-NMAc), 2'-O-[2-(dimethylamino)-2-oxoethyl] (2'-O-DMAc), and 2'-O-[2-[[2-(dimethylamino)ethyl]amino]-2-oxoethyl] (2'-O-DMAEAc), have been synthesized. These modified oligonucleotides exhibit high binding affinity to complementary RNA (and not to DNA) and considerably enhance the nuclease stability of oligonucleotides with t(1/2) > 24 h.
Bio Calculators
Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

Calculate
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g
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