Thalidomide-O-amido-C6-NH2 (TFA) - CAS 1950635-14-9

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BP-100001 100 mg $439 In stock
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Thalidomide-O-amido-C6-Amine trifluoroacetate is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.

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Molecular Formula
Molecular Weight

Thalidomide-O-amido-C6-NH2 (TFA)

    • Specification
      • Solubility
        DMSO : ≥ 105.5 mg/mL
        4°C, stored under nitrogen
        *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
        Room temperature in continental US; may vary elsewhere
        Thalidomide-O-amido-C6-NH2 (TFA); Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA); Thalidomide-O-amido-C6-Amine Trifluoroacetate; N-(6-aminohexyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;2,2,2-trifluoroacetic acid
    • Properties
      • InChI Key
        Canonical SMILES
    • Reference Reading
      • 1. Global Surveillance of trans-Fatty Acids
        Hubert W Vesper, Chaoyang Li, Samira Asma, Laura K Cobb Prev Chronic Dis . 2019 Oct 31;16:E147. doi: 10.5888/pcd16.190121.
        Trans-fatty acid (TFA) intake can increase the risk of coronary heart disease (CHD) morbidity and mortality and all-cause mortality. Industrially produced TFAs and ruminant TFAs are the major sources in foods. TFA intake and TFA-attributed CHD mortality vary widely worldwide. Excessive TFA intake is a health threat in high-income countries; however, it is also a threat in low- and middle-income countries (LMICs). Data on TFA intake are scarce in many LMICs and an urgent need exists to monitor TFAs globally. We reviewed global TFA intake and TFA-attributed CHD mortality and current progress toward policy or regulation on elimination of industrially produced TFAs in foods worldwide. Human biological tissues can be used as biomarkers of TFAs because they reflect actual intake from various foods. Measuring blood TFA levels is a direct and reliable method to quantify TFA intake.
        2. Trans-Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation
        Mateusz M Wilczek, Robert Olszewski, Andrzej Krupienicz Cardiology . 2017;138(4):254-258. doi: 10.1159/000479956.
        Hydrogenated oils containing trans-fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased all-cause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) incidence. Denmark was the first country to introduce a law that limited TFA content in food; this action led to lower CVD mortality. So far 7 European countries have followed this practice, in a few others the food industry voluntarily reduced TFA use. The issue remains mostly unaddressed in the rest of the world. Legal TFA limits should be commonly established as they are the optimal solution considering both CVD prevention and the associated cost savings in public healthcare.
        3. The evidence of politics in trans-fatty acid regulation in Mexico
        Ekow Adom Mensah, Nataliia Gavkalova, Israel Oluwaseyidayo Idris Salud Publica Mex . 2021 Feb 26;63(2, Mar-Abr):268-273. doi: 10.21149/11186.
        According to the World Health Organization, coronary heart disease (CHD)-caused deaths accounted for one-fifth of the total deaths in Mexico in 2017. Researches done in the past have confirmed the association between dietary trans-fatty acids (TFA) and CHD. Dietary TFA are mostly derived from industrial-hydrogenated oils, milk products, and meat fats. This paper is a build on of a policy paper done on international policies for TFA in low-to-middle income countries, using Mexico as the case study. This write up, however, aims to critically analyse the TFA regulation policy process in Mexico, evaluating the strength of evidence proposed and identifying the barriers preventing the usage of the evidence for a TFA regulation policy implementation. Although evidence abounds for TFA regulation policy, lack of effective collaboration and communication among the major actors (researchers, policy-makers, and consumers) in Mexico remains a major setback in its implementation.
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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