(S,R,S)-AHPC-C2-NH2 dihydrochloride

 CAS No.: 2341796-73-2  Cat No.: BP-100100  Purity: ≥95% by HPLC 4.5  

(S,R,S)-AHPC-C2-NH2 dihydrochloride contains the von-Hippel-Lindau (VHL) protein ligand and an alkyl linker with a terminal amine for conjugation to a target protein ligand, which can be used as a part of designed PROTAC molecules.

(S,R,S)-AHPC-C2-NH2 dihydrochloride

Structure of 2341796-73-2

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C₂₅H₃₇Cl₂N₅O₄S
Molecular Weight
574.56

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95% by HPLC
Solubility
In DMSO: 250 mg/mL (435.12 mM; Need ultrasonic)
Storage
4°C, protect from light, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
(2S,4R)-1-[(2S)-2-(3-aminopropanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;dihydrochloride
Synonyms
VH 032 - linker 7
InChI
1S/C25H35N5O4S.2ClH/c1-15-21(35-14-28-15)17-7-5-16(6-8-17)12-27-23(33)19-11-18(31)13-30(19)24(34)22(25(2,3)4)29-20(32)9-10-26;;/h5-8,14,18-19,22,31H,9-13,26H2,1-4H3,(H,27,33)(H,29,32);2*1H/t18-,19+,22-;;/m1../s1
Canonical SMILES
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCN)=O)=O)O)=O)SC=N1.Cl.Cl

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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