1. Nanocurcumin, Promising Potential Protective Agent Against Histopathological Damage in the Cerebral Cortex of Mice Induced by Aluminum Chloride
Yulia Irnidayanti, Fudchus Tifany Nabilah, Nina Herlina Pak J Biol Sci. 2022 Jan;25(6):560-568.doi: 10.3923/pjbs.2022.560.568.
Background and Objective: Aluminum (Al) is widely used in many aspects of daily life, such as food packaging, cooking utensil components, food additives, cosmetics and water distillation. This study aimed to evaluate the protective role of nanocurcumin on the cerebral cortex of one and two-month-old mice exposed to 200 mg kg1 b.wt., aluminium. Materials and Methods: The Swiss Webster mice were used in this study. The control group only received sterile distilled water, the Al group was administered 200 mg kg1 b.wt., of AlCl3 solution and the Al+Na Cur group was administered 200 mg kg1 b.wt., AlCl3+200 mg kg1 nanocurcumin by intraperitoneal injection. The nanocurcumin was administered one hour after AlCl3 exposure and then on days 0, 3, 6, 9, 12, 15, 18, 21, 24, 27 and 30. All the mice were anaesthetized and their brains were collected and fixed in a neutral formalin buffer solution for histological analysis. The paraffin method was used in this study. Results: The death of granular neuron cells and karyolysis cells and the vacuolation of the pyramid cell layer of the cerebral cortex could be prevented by the intraperitoneal administration of nanocurcumin. The effect of nanocurcumin administration on the Al group at two months of age was more effective than on the Al group at one month of age. Conclusion: Nanocurcumin can be a promising candidate protective agent against cerebral cortex changes after aluminium administration.
2. Privacy protection of medical data in social network
Jie Su, Yi Cao, Yuehui Chen, Yahui Liu, Jinming Song BMC Med Inform Decis Mak. 2021 Oct 18;21(Suppl 1):286.doi: 10.1186/s12911-021-01645-0.
Background:Protection of privacy data published in the health care field is an important research field. The Health Insurance Portability and Accountability Act (HIPAA) in the USA is the current legislation for privacy protection. However, the Institute of Medicine Committee on Health Research and the Privacy of Health Information recently concluded that HIPAA cannot adequately safeguard the privacy, while at the same time researchers cannot use the medical data for effective researches. Therefore, more effective privacy protection methods are urgently needed to ensure the security of released medical data.
3. Efficacy of Dust and Wettable Powder Formulation of Diatomaceous Earth (Detech®) in the Control of Tyrophagus putrescentiae (Schrank) (Acari: Acaridae)
Nihal Kılıç Insects. 2022 Sep 20;13(10):857.doi: 10.3390/insects13100857.
Tyrophagus putrescentiae (Schrank) (Acari: Acaridae) is a cosmopolite mite species commonly in found food and stored products. In this study, the acaricidal activity of two Turkish diatomaceous earth (DE) formulations (Detech® WP95 and Detech® Dust) were applied on a concrete surface at five different concentrations (1, 2.5, 5, 7.5, and 10 g/m2) and dead individuals were counted at 11 different time intervals (1, 3, 6, 9, 12, 15, 18, 21, 24, 27, and 30 h) at a temperature of 25 ± 1 °C and 75 ± 5% relative humidity (RH). Mite mortalities were observed after 6- and 18-hour exposure periods at all concentrations of dust and wettable powder (WP) formulations, respectively. Specifically, 100% mortality for the WP formulation was achieved at the highest concentration of 10 g/m2 after 15 h of exposure and after 27 h and 30 h for the lowest concentration. In the case of dust formulation, mortalities were observed after 3 h of exposure at all concentrations except at 1 g/m2, while a 100% mortality rate was achieved after 21 h of exposure to all concentrations and after 18 h of exposure for 7.5 g/m2 and 10 g/m2. This study indicates that both WP and dust formulations of local diatomaceous earth can cause 100% mortality in 24 h on average and can be a promising alternative to conventional chemical acaricides.
