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Bis-PEG5-acid - CAS 439114-13-3

Name: Bis-PEG5-acid
Brand: BOC Sciences
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Bis-PEG5-acid is a polyethylene glycol (PEG)-based PROTAC linker. Bis-PEG5-acid can be used in the synthesis of a series of PROTACs.

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Molecular Formula

C14H26O9

Molecular Weight

338.35

Bis-PEG5-acid

- Specification
  - Related CAS
    
    51178-68-8 (polymer)
    
    Purity
    
    95%
    
    Solubility
    
    Soluble in DMSO
    
    Appearance
    
    Pale Yellow or Colorless Oily Liquid
    
    Application
    
    A dicarboxylic acid used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction.
    
    Storage
    
    Store at 2-8°C
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    3-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
    
    Synonyms
    
    α,ω-dipropionic acid tetraethylene glycol; HOOCCH2CH2O-PEG4-CH2CH2COOH; 4,7,10,13,16-Pentaoxanonadecanedioic Acid; 4,7,10,13,16-Pentaoxanonadecane-1,19-dioic acid
- Properties
  - Boiling Point
    
    513.6±50.0 °C at 760 mmHg
    
    Density
    
    1.205±0.06 g/cm3 (Predicted)
    
    InChI Key
    
    VRTJBJNTMHDBAI-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C14H26O9/c15-13(16)1-3-19-5-7-21-9-11-23-12-10-22-8-6-20-4-2-14(17)18/h1-12H2,(H,15,16)(H,17,18)
    
    Canonical SMILES
    
    C(COCCOCCOCCOCCOCCC(=O)O)C(=O)O
- Reference Reading
  - 1.Cocirculation of Plasmodium and Bacterial Deoxyribonucleic Acids in Blood of Febrile and Afebrile Children from Urban and Rural Areas in Gabon.
    
    Mourembou G1, Nzondo SM1, Ndjoyi-Mbiguino A1, Lekana-Douki JB1, Kouna LC1, Matsiegui PB1, Manego RZ1, Moukandja IP1, Keïta AK1, Tissot-Dupont H1, Fenollar F1, Raoult D2. Am J Trop Med Hyg. 2016 Apr 25. pii: 15-0751. [Epub ahead of print]
    
    Malaria is considered to be the most common etiology of fever in sub-Saharan Africa while bacteremias exist but are under assessed. This study aimed to assess bacteremias and malaria in children from urban and rural areas in Gabon. DNA extracts from blood samples of 410 febrile and 60 afebrile children were analyzed using quantitative polymerase chain reaction. Plasmodium spp. was the microorganism most frequently detected in febrile (78.8%, 323/410) and afebrile (13.3%, 8/60) children, (P < 0.001). DNA from one or several bacteria were detected in 17 febrile patients (3.7%) but not in the controls (P = 0.1). This DNA was more frequently detected as coinfections among febrile children testing positive for Plasmodium (4.6%, 15/323) than in those testing negative for Plasmodium (0%, 0/87; P = 0.04). The bacteria detected were Streptococcus pneumoniae 2.4% (10/410), Staphylococcus aureus 1.7% (7/410), Salmonella spp. 0.7% (3/410), Streptococcus pyogenes 0.
    
    2.Folate/Folic Acid Knowledge, Intake, and Self-Efficacy of College-Age Women: Impact of Text Messaging and Availability of a Folic Acid-Containing Supplement.
    
    Rampersaud GC1, Sokolow A1, Gruspe A1, Colee JC1, Kauwell GP1. J Am Coll Health. 2016 Apr 19:0. [Epub ahead of print]
    
    OBJECTIVE: Evaluate the impact of educational text messages (TM) on folate/folic acid knowledge and consumption among college-age women, and to evaluate the impact of providing folic acid supplements on folate/folic acid intake among college-age women.

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