Bis-PEG5-acid

 CAS No.: 439114-13-3  Cat No.: BP-500054  Purity: 95% 4.5  

Bis-PEG5-acid is a polyethylene glycol (PEG)-based PROTAC linker. Bis-PEG5-acid can be used in the synthesis of a series of PROTACs.

Bis-PEG5-acid

Structure of 439114-13-3

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Category
PROTAC Linker
Molecular Formula
C14H26O9
Molecular Weight
338.35
Appearance
Pale Yellow or Colorless Oily Liquid

* For research and manufacturing use only. Not for human or clinical use.

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Popular Publications Citing BOC Sciences Products
Purity
95%
Solubility
Soluble in DMSO
Appearance
Pale Yellow or Colorless Oily Liquid
Application
A dicarboxylic acid used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction.
Storage
Store at 2-8°C
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
3-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
α,ω-dipropionic acid tetraethylene glycol; HOOCCH2CH2O-PEG4-CH2CH2COOH; 4,7,10,13,16-Pentaoxanonadecanedioic Acid; 4,7,10,13,16-Pentaoxanonadecane-1,19-dioic acid
Boiling Point
513.6±50.0 °C at 760 mmHg
Density
1.205±0.06 g/cm3 (Predicted)
InChI Key
VRTJBJNTMHDBAI-UHFFFAOYSA-N
InChI
InChI=1S/C14H26O9/c15-13(16)1-3-19-5-7-21-9-11-23-12-10-22-8-6-20-4-2-14(17)18/h1-12H2,(H,15,16)(H,17,18)
Canonical SMILES
C(COCCOCCOCCOCCOCCC(=O)O)C(=O)O
1.Cocirculation of Plasmodium and Bacterial Deoxyribonucleic Acids in Blood of Febrile and Afebrile Children from Urban and Rural Areas in Gabon.
Mourembou G1, Nzondo SM1, Ndjoyi-Mbiguino A1, Lekana-Douki JB1, Kouna LC1, Matsiegui PB1, Manego RZ1, Moukandja IP1, Keïta AK1, Tissot-Dupont H1, Fenollar F1, Raoult D2. Am J Trop Med Hyg. 2016 Apr 25. pii: 15-0751. [Epub ahead of print]
Malaria is considered to be the most common etiology of fever in sub-Saharan Africa while bacteremias exist but are under assessed. This study aimed to assess bacteremias and malaria in children from urban and rural areas in Gabon. DNA extracts from blood samples of 410 febrile and 60 afebrile children were analyzed using quantitative polymerase chain reaction. Plasmodium spp. was the microorganism most frequently detected in febrile (78.8%, 323/410) and afebrile (13.3%, 8/60) children, (P < 0.001). DNA from one or several bacteria were detected in 17 febrile patients (3.7%) but not in the controls (P = 0.1). This DNA was more frequently detected as coinfections among febrile children testing positive for Plasmodium (4.6%, 15/323) than in those testing negative for Plasmodium (0%, 0/87; P = 0.04). The bacteria detected were Streptococcus pneumoniae 2.4% (10/410), Staphylococcus aureus 1.7% (7/410), Salmonella spp. 0.7% (3/410), Streptococcus pyogenes 0.
2.Folate/Folic Acid Knowledge, Intake, and Self-Efficacy of College-Age Women: Impact of Text Messaging and Availability of a Folic Acid-Containing Supplement.
Rampersaud GC1, Sokolow A1, Gruspe A1, Colee JC1, Kauwell GP1. J Am Coll Health. 2016 Apr 19:0. [Epub ahead of print]
OBJECTIVE: Evaluate the impact of educational text messages (TM) on folate/folic acid knowledge and consumption among college-age women, and to evaluate the impact of providing folic acid supplements on folate/folic acid intake among college-age women.

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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