Name: Bis-PEG5-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

95%

Solubility

Soluble in DMSO

Appearance

Pale Yellow or Colorless Oily Liquid

Application

A dicarboxylic acid used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction.

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

α,ω-dipropionic acid tetraethylene glycol; HOOCCH2CH2O-PEG4-CH2CH2COOH; 4,7,10,13,16-Pentaoxanonadecanedioic Acid; 4,7,10,13,16-Pentaoxanonadecane-1,19-dioic acid

Boiling Point

513.6±50.0 °C at 760 mmHg

Density

1.205±0.06 g/cm3 (Predicted)

InChI Key

VRTJBJNTMHDBAI-UHFFFAOYSA-N

InChI

InChI=1S/C14H26O9/c15-13(16)1-3-19-5-7-21-9-11-23-12-10-22-8-6-20-4-2-14(17)18/h1-12H2,(H,15,16)(H,17,18)

SMILES

C(COCCOCCOCCOCCOCCC(=O)O)C(=O)O

1.Cocirculation of Plasmodium and Bacterial Deoxyribonucleic Acids in Blood of Febrile and Afebrile Children from Urban and Rural Areas in Gabon.

Mourembou G1, Nzondo SM1, Ndjoyi-Mbiguino A1, Lekana-Douki JB1, Kouna LC1, Matsiegui PB1, Manego RZ1, Moukandja IP1, Keïta AK1, Tissot-Dupont H1, Fenollar F1, Raoult D2. Am J Trop Med Hyg. 2016 Apr 25. pii: 15-0751. [Epub ahead of print]

Malaria is considered to be the most common etiology of fever in sub-Saharan Africa while bacteremias exist but are under assessed. This study aimed to assess bacteremias and malaria in children from urban and rural areas in Gabon. DNA extracts from blood samples of 410 febrile and 60 afebrile children were analyzed using quantitative polymerase chain reaction. Plasmodium spp. was the microorganism most frequently detected in febrile (78.8%, 323/410) and afebrile (13.3%, 8/60) children, (P < 0.001). DNA from one or several bacteria were detected in 17 febrile patients (3.7%) but not in the controls (P = 0.1). This DNA was more frequently detected as coinfections among febrile children testing positive for Plasmodium (4.6%, 15/323) than in those testing negative for Plasmodium (0%, 0/87; P = 0.04). The bacteria detected were Streptococcus pneumoniae 2.4% (10/410), Staphylococcus aureus 1.7% (7/410), Salmonella spp. 0.7% (3/410), Streptococcus pyogenes 0.

2.Folate/Folic Acid Knowledge, Intake, and Self-Efficacy of College-Age Women: Impact of Text Messaging and Availability of a Folic Acid-Containing Supplement.

Rampersaud GC1, Sokolow A1, Gruspe A1, Colee JC1, Kauwell GP1. J Am Coll Health. 2016 Apr 19:0. [Epub ahead of print]

OBJECTIVE: Evaluate the impact of educational text messages (TM) on folate/folic acid knowledge and consumption among college-age women, and to evaluate the impact of providing folic acid supplements on folate/folic acid intake among college-age women.

Bis-PEG5-acid, is designed to provide a flexible, hydrophilic polyethylene glycol-based spacer that can be used to connect binding motifs and tune the effective geometry of ternary complex formation. Its carboxylic acid functionality supports robust conjugation strategies, while the PEG character can improve solubility and reduce nonspecific hydrophobic interactions. The detailed structural and synthetic considerations for PROTAC assembly are provided below.

Structure: Bis-PEG5-acid is a PEG-based bis-functional linker featuring ether linkages within a flexible polymeric chain and terminal carboxylic acid groups. The presence of multiple oxygen atoms enables strong hydrogen-bonding and contributes to water compatibility, while the carbon–oxygen framework provides conformational flexibility relevant to linker-mediated distance control.

Reactivity: The carboxylic acid groups are suitable for standard PROTAC conjugation chemistries that form stable amide or ester linkages with complementary nucleophiles. Typical approaches employ activating reagents such as carbodiimides or uronium-type coupling agents, often with bases, under anhydrous or mixed-solvent conditions to minimize hydrolysis. Solvents like DMF, DMSO, or dichloromethane are commonly used, and reaction progress is monitored to ensure efficient coupling while preserving sensitive functional groups.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂