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(S,R,S)-AHPC-C3-NH2 - CAS 2245697-83-8

Inquiry

(S,R,S)-AHPC-C3-NH2 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

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Molecular Formula

C27H40ClN5O4S

Molecular Weight

566.16

(S,R,S)-AHPC-C3-NH2

- Specification
  - Solubility
    
    DMSO : ≥ 109.6 mg/mL;H2O : ≥ 50 mg/mL
    
    Storage
    
    Powder
    -20°C
    3 years
    
    4°C
    2 years
    
    In solvent
    -80°C
    6 months
    
    -20°C
    1 month
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere
    
    Synonyms
    
    (S,R,S)-AHPC-C3-NH2; VH032-C3-NH2; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28; (2S,4R)-1-[(2S)-2-(5-aminopentanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;hydrochloride; Protac linker 5
- Properties
  - InChI Key
    
    HJICCZROGLAHNB-BIBCNAKVSA-N
    
    InChI
    
    InChI=1S/C27H39N5O4S.ClH/c1-17-23(37-16-30-17)19-10-8-18(9-11-19)14-29-25(35)21-13-20(33)15-32(21)26(36)24(27(2,3)4)31-22(34)7-5-6-12-28;/h8-11,16,20-21,24,33H,5-7,12-15,28H2,1-4H3,(H,29,35)(H,31,34);1H/t20-,21+,24-;/m1./s1
    
    Canonical SMILES
    
    CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCN)O.Cl
- Reference Reading
  - 1. A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function
    
    Kelsey M Pinckard, Vikram K Shettigar, Katherine R Wright, et al. Circulation. 2021 Jan 12;143(2):145-159.doi: 10.1161/CIRCULATIONAHA.120.049813.Epub 2020 Oct 27.
    
    Background:Brown adipose tissue (BAT) is an important tissue for thermogenesis, making it a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular disease, and recent studies have also identified BAT as an endocrine organ. Although BAT has been implicated to be protective in cardiovascular disease, to this point there are no studies that identify a direct role for BAT to mediate cardiac function.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂

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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳

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