(S,R,S)-AHPC-PEG2-NH2 hydrochloride - CAS 2097973-72-1

(S,R,S)-AHPC-PEG2-NH2 hydrochloride is a crosslinker−E3 ligase ligand conjugate consisting of a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

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Molecular Formula
Molecular Weight
575.72 (free base)

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

    • Specification
      • Synonyms
        (2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
        Shelf Life
        2 years
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