1. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Haibo Liu, Haiyan Yu, Jun Xia, Ling Liu, Guan J Liu, Hong Sang, Frank Peinemann Meta-AnalysisCochrane Database Syst Rev. 2020 May 1;5(5):CD011368.doi: 10.1002/14651858.CD011368.pub2.
Background:Acne is an inflammatory disorder with a high global burden. It is common in adolescents and primarily affects sebaceous gland-rich areas. The clinical benefit of the topical acne treatments azelaic acid, salicylic acid, nicotinamide, sulphur, zinc, and alpha-hydroxy acid is unclear.Objectives:To assess the effects of topical treatments (azelaic acid, salicylic acid, nicotinamide, zinc, alpha-hydroxy acid, and sulphur) for acne.Search
2. Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis
Gilles Jadd Hoilat, Mohamad Fekredeen Ayas, Judie Noemie Hoilat, Ahmed Abu-Zaid, Ceren Durer, Seren Durer, Talal Adhami, Savio John BMJ Open Gastroenterol. 2021 May;8(1):e000648.doi: 10.1136/bmjgast-2021-000648.
Background:Hepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. Lactulose is the standard of care till this date; however, polyethylene glycol (PEG) has gained the attention of multiple investigators.
3. Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial
Lixia Pei, Hao Geng, Jing Guo, Guohui Yang, Lin Wang, Rongrong Shen, Shuyu Xia, Min Ding, Hua Feng, Jin Lu, Jing Li, Lian Liu, Yanye Shu, Xiangdong Fang, Xiaoliang Wu, Xiaoxiao Wang, Shengjie Weng, Lu Ju, Xiao Chen, Hong Shen, Jianhua Sun0 Mayo Clin Proc. 2020 Aug;95(8):1671-1683.doi: 10.1016/j.mayocp.2020.01.042.Epub 2020 Jun 1.
Objective:To evaluate the effect and safety of acupuncture for the treatment of irritable bowel syndrome (IBS) through comparisons with those of polyethylene glycol (PEG) 4000 and pinaverium bromide.Patients and methods:This multicenter randomized controlled trial was conducted at 7 hospitals in China and enrolled participants who met the Rome III diagnostic criteria for IBS between May 3, 2015, and June 29, 2018. Participants were first stratified into constipation-predominant or diarrhea-predominant IBS group. Participants in each group were randomly assigned in a 2:1 ratio to receive acupuncture (18 sessions) or PEG 4000 (20 g/d, for IBS-C)/pinaverium bromide (150 mg/d, for IBS-D) over a 6-week period, followed by a 12-week follow-up. The primary outcome was change in total IBS-Symptom Severity Score from baseline to week 6. Results:Of 531 patients with IBS who were randomized, 519 (344 in the acupuncture group and 175 in the PEG 4000/ pinaverium bromide group) were included in the full analysis set. From baseline to 6 weeks, the total IBS-Symptom Severity Score decreased by 123.51 (95% CI, 116.61 to 130.42) in the acupuncture group and 94.73 (95% CI, 85.03 to 104.43) in the PEG 4000/pinaverium bromide group. The between-group difference was 28.78 (95% CI, 16.84 to 40.72; P<.001). No participant experienced severe adverse effects.Conclusion:Acupuncture may be more effective than PEG 4000 or pinaverium bromide for the treatment of IBS, with effects lasting up to 12 weeks.Trial registration:Chinese Clinical Trials Register, ChiCTR-IOR-15006259.
CAS No.: 1119249-30-7
Purity: 95%
