1. (Pyridino-15-crown-5-κN,O,O',O'',O''')bis-(thio-cyanato-κN)manganese(II)
Chengjuan Li, Zejing Feng, Dacheng Li, Daqi Wang Acta Crystallogr Sect E Struct Rep Online. 2008 Mar 14;64(Pt 4):m557.doi: 10.1107/S160053680800679X.
The title complex, [Mn(NCS)(2)(C(13)H(19)NO(4))] {systematic name: [3,6,9,12-tetra-oxa-18-aza-bicyclo-[12.3.1]octa-cosa-14(18),15,17-triene-κ(5)N,O,O',O'',O''']bis-(thio-cyanato-κN)manganese(I-I)}, was obtained by the reaction of MnCl(2)·4H(2)O and NaSCN with pyridino-15-crown-5. The Mn(2+) center has a distorted penta-gonal bipyramidal coordination geometry, coordinated by four O atoms and one N atom of the pyridino-15-crown-5 mol-ecule, and by the N atoms of the two NCS(-) ligands.
2. LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial
Shweta Urva, Tamer Coskun, Mei Teng Loh, Yu Du, Melissa K Thomas, Sirel Gurbuz, Axel Haupt, Charles T Benson, Martha Hernandez-Illas, David A D'Alessio, Zvonko Milicevic Clinical TrialLancet. 2022 Nov 26;400(10366):1869-1881.doi: 10.1016/S0140-6736(22)02033-5.Epub 2022 Oct 27.
Background:Treating hyperglycaemia and obesity in individuals with type 2 diabetes using multi-receptor agonists can improve short-term and long-term outcomes. LY3437943 is a single peptide with agonist activity for glucagon, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1) receptors that is currently in development for the treatment of type 2 diabetes and for the treatment of obesity and associated comorbidities. We investigated the safety, pharmacokinetics, and pharmacodynamics of multiple weekly doses of LY3437943 in people with type 2 diabetes in a 12-week study.
3. [μ-6,9-Bis(carboxylatomethyl)-3,12-bis(car-boxymethyl)-3,6,9,12-tetraaza-tetradecanedioato]bis-[aqua-cobalt(II)] tetra-hydrate
Qi-Feng Qian, Jin-Hui Wu, Jin-Liang Qian Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):m97.doi: 10.1107/S1600536813000196.Epub 2013 Jan 12.
The binuclear title complex, [Co(2)(C(18)H(26)N(4)O(12))(H(2)O)(2)]·4H(2)O, lies about a centre of inversion, the Co(II) atom being coordinated in a distorted octa-hedral arrangement defined by one water mol-ecule and N(2)O(3) donors derived from one end of a 6,9-bis(carboxylatomethyl)-3,12-bis(car-boxy-methyl)-3,6,9,12-tetraaza-tetradecanedioate (H(2)TTHA(4-)) tetra-anion. In the crystal, numerous O-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network.
