1,1,1-Trifluoroethyl-PEG4-aminooxy
CAS No.: 1895922-78-7
Cat No.: BP-501455
4.5 
1,1,1-Trifluoroethyl-PEG4-aminooxy is a heterobifunctional PEG-based linker featuring a terminal aminooxy group for oxime/oxime-like conjugation chemistry and a PEG4 chain that provides aqueous solubility, conformational flexibility, and spatial separation between PROTAC components. The trifluoroethyl substituent increases hydrophobic character and can modulate physicochemical properties such as partitioning and stability of the linker under typical synthetic and handling conditions. In PROTAC design, the aminooxy handle is commonly used to connect a targeting ligand or effector moiety bearing a complementary carbonyl group, enabling formation of stable oxime linkages that preserve the geometry needed for productive ternary complex formation. The PEG spacer helps reduce steric hindrance and can improve the accessibility of binding motifs to their respective targets. This linker is valuable for constructing modular, water-compatible PROTACs and related targeted protein degradation probes where controlled conjugation and reliable linker behavior are required.
Structure of 1895922-78-7
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1,1,1-Trifluoroethyl-PEG4-aminooxy is a PEG-based aminooxy linker designed for modular PROTAC assembly, enabling efficient conjugation between a targeting ligand and an E3-recruiting element through aminooxy-reactive chemistry. Its ether-rich, flexible polyethylene glycol scaffold promotes solubility and favorable linker dynamics, which can help preserve productive ternary complex formation. The trifluoroethyl group provides a defined hydrophobic/fluorinated handle that can tune physicochemical behavior. Detailed structural and synthetic guidance is provided below.
Structure: The linker contains an aminooxy functional group for oxime-forming conjugation, connected to a polyethylene glycol chain that provides flexibility and multiple ether oxygen atoms. A trifluoroethyl substituent introduces a fluorinated moiety, while the overall scaffold features stable C–O and C–C linkages suitable for bioconjugation workflows.
Reactivity: Aminooxy linkers are commonly used to form oxime linkages with carbonyl-containing partners under mild conditions, typically using an aniline-free oxime formation strategy and controlled pH to drive condensation. The reaction proceeds via nucleophilic addition of the aminooxy to an aldehyde or ketone, followed by dehydration to yield a stable C=N bond. Suitable solvents include aqueous buffers with compatible co-solvents, and no special catalysts are generally required beyond pH control.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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