Name: mPEG3-acetic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Price

Stock

Quantity

$--

In stock

Purity

>97%

Appearance

Colorless or Light Yellowish Liquid

Storage

Pure form, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetic acid

Synonyms

2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetic acid; 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetic acid

Boiling Point

338.4±27.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

BCGLNCAVZDQPGE-UHFFFAOYSA-N

InChI

InChI=1S/C9H18O6/c1-12-2-3-13-4-5-14-6-7-15-8-9(10)11/h2-8H2,1H3,(H,10,11)

SMILES

COCCOCCOCCOCC(=O)O

1. Kinetics of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions

H C Margolis, E C Moreno Calcif Tissue Int. 1992 Feb;50(2):137-43.doi: 10.1007/BF00298791.

The present study was undertaken in an attempt to relate the kinetics of hydroxyapatite dissolution to solution parameters, under experimental conditions relevant to the dental caries process. Thus, the dissolution of hydroxyapatite was studied in acetic, lactic, and dilute phosphoric acid solutions having initial pH values from 4 to 6. Rates of dissolution and the corresponding degree of saturation with respect to hydroxyapatite were determined at various times throughout the dissolution process. Rates of dissolution of all solutions were found to decrease with increasing degree of solution saturation and were greater in solutions with lower initial values of pH. However, rates of dissolution in partially saturated phosphoric acid solutions (without added organic acid) were at least one order of magnitude lower than those observed in the organic acid buffers with the same initial pH, over the same range of saturation values. The data obtained are consistent with a surface-controlled dissolution model in which the rate of dissolution is dependent upon the degree of saturation and the sum of the activities of the acidic species in solution, i.e., phosphoric and organic acids. These results suggest that in order to assess the cariogenic potential of a given medium (e.g., plaque fluid), one must determine both the degree of saturation with respect to the dissolving mineral and the activities of acidic species in solution.

This mPEG3-acetic acid linker is designed to provide a compact, hydrophilic polyethylene glycol segment capped with a carboxylic acid handle for downstream conjugation in targeted protein degradation workflows. Its PEG-based architecture supports improved aqueous solubility and can help tune linker polarity and overall PROTAC physicochemical behavior. The following sections describe its structural features and practical reactivity considerations for constructing PROTACs using this building block.

Structure: The molecule comprises a short methoxy-terminated polyethylene glycol chain linked to an acetic acid moiety. It contains ether linkages within the PEG segment and a terminal carboxylic acid functional group, enabling robust hydrogen-bonding interactions and amphiphilic behavior in aqueous media.

Reactivity: The carboxylic acid group is suitable for amide-bond formation with primary or activated amine partners commonly used in PROTAC assembly. Typical approaches include carbodiimide-mediated coupling or use of activated acid derivatives under mild, aqueous or mixed-solvent conditions, often with base to promote nucleophilic acyl substitution. Careful control of pH and reagent compatibility is recommended to preserve PEG integrity and minimize side reactions.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂