(+)-Biotin-PEG12-OH
Cat No.: BP-502056
4.5 
(+)-Biotin-PEG12-OH is a chiral, biotin-functionalized polyethylene glycol linker featuring a terminal hydroxyl group and an extended PEG chain length that provides conformational flexibility and aqueous solubility. The biotin moiety enables high-affinity binding to streptavidin or avidin, allowing researchers to position or immobilize PROTAC components, conjugates, or assay reagents through a robust noncovalent interaction. In targeted protein degradation workflows, such biotin–PEG linkers are commonly used to tether bulky ligands to carrier scaffolds, to facilitate controlled assembly of multicomponent systems, or to support pull-down and localization experiments that validate ternary-complex formation and degradation engagement. The PEG spacer helps minimize steric interference between binding partners, improving accessibility of functional groups during conjugation and downstream biochemical assays. This makes (+)-Biotin-PEG12-OH a practical tool for designing and characterizing PROTAC-linked constructs and for strengthening experimental readouts in targeted degradation research.
-biotin-peg12-oh.gif)
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
(+)-Biotin-PEG12-OH is a biotin-functionalized polyethylene glycol linker designed for constructing PROTACs and related targeted degradation tools. Its PEG-based spacer provides conformational flexibility and improved solubility, while the biotin handle enables robust conjugation to biotin-binding systems used in experimental workflows. The combination supports efficient assembly of bifunctional degraders and can help maintain productive geometry between targeting and recruitment modules. Detailed structural and reactivity considerations follow below.
Structure: The linker comprises a terminal hydroxyl group connected through a long, repeating ethylene glycol (PEG) chain, terminating in a biotin-derived moiety. It contains ether linkages within the PEG backbone and amide/heterocyclic features characteristic of biotin, yielding a hydrophilic, flexible scaffold.
Reactivity: The terminal hydroxyl enables standard PROTAC linker installation strategies such as conversion to activated derivatives (for example, carbonate, ester, or other leaving-group forms) prior to coupling with amine- or carboxyl-bearing ligands. Conjugation is typically performed under mild base conditions in polar organic solvents, maintaining PEG stability. Mechanistically, coupling proceeds via nucleophilic substitution or acyl-transfer pathways depending on the activated intermediate; catalysts are selected to match the chosen activation chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
