(+)-Biotin-PEG10-OH
Cat No.: BP-502048
4.5 
(+)-Biotin-PEG10-OH is a chiral, biotin-functionalized polyethylene glycol (PEG) linker featuring a terminal carboxylic acid that enables straightforward conjugation chemistry and subsequent coupling to PROTAC-related components. Structurally, it combines the high-affinity biotin motif with a hydrophilic PEG spacer of approximately ten ethylene glycol units, which improves aqueous solubility, reduces nonspecific adsorption, and provides conformational flexibility between the biotin handle and the attachment site. In targeted protein degradation workflows, such linkers are useful for positioning or tethering PROTAC building blocks to affinity reagents, capture surfaces, or detection/immobilization formats, thereby facilitating controlled assembly, purification, and characterization of degradation constructs. The terminal hydroxyl/acid functionality supports routine ester or amide formation strategies, allowing researchers to integrate the linker into experimental systems that require stable biotin-mediated interactions while maintaining favorable linker dynamics for effective molecular recognition.
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* For research and manufacturing use only. Not for human or clinical use.
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(+)-Biotin-PEG10-OH is a biotin-functionalized polyethylene glycol linker designed for modular conjugation in targeted protein degradation workflows. Its PEG-based spacer provides hydrophilic, flexible spacing that can improve solubility and reduce steric interference between binding elements in PROTAC constructs. Biotin functionality enables reliable attachment to biotin-binding platforms, supporting streamlined assembly and characterization of degradation scaffolds. The following points describe the linker’s structure and practical reactivity considerations in detail below.
Structure: The linker consists of a biotin moiety connected through a polyethylene glycol chain terminated with a hydroxyl group. It features ether linkages within the PEG segment, amide-free ether connectivity, and a terminal alcohol suitable for further derivatization. Overall, it is highly hydrophilic and conformationally flexible.
Reactivity: The terminal hydroxyl can be converted to activated derivatives (for example, carbonate or ester forms) to enable coupling with amine- or hydrazide-bearing partners used in PROTAC synthesis. Typical approaches rely on standard organic coupling chemistry under mild, anhydrous conditions, often using base and coupling reagents compatible with PEG stability. Solvents such as polar aprotic media are commonly used to maintain solubility and reaction efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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