(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

 CAS No.: 2376990-26-8  Cat No.: BP-100126  Purity: ≥95% by HPLC 4.5  

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride is a synthetic E3 ligand-linker conjugate containing a von-Hippel-Lindau (VHL) ligand based on (S,R,S)-AHPC and a C4 alkyl linker with terminal amine for covalent binding, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand.

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

Structure of 2376990-26-8

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C₂₈H₄₃Cl₂N₅O₅S
Molecular Weight
632.64

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95% by HPLC
Storage
Store at -20°C
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Room temperature in continental US; may vary elsewhere.
IUPACName
(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[[2-(4-aminobutoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-hydroxypyrrolidine-2-carboxamide;dihydrochloride
Synonyms
VH032-phenol-C4-NH2 dihydrochloride
InChI
1S/C28H41N5O5S.2ClH/c1-17-24(39-16-31-17)19-8-9-20(23(12-19)38-11-7-6-10-29)14-30-26(36)22-13-21(35)15-33(22)27(37)25(28(3,4)5)32-18(2)34;;/h8-9,12,16,21-22,25,35H,6-7,10-11,13-15,29H2,1-5H3,(H,30,36)(H,32,34);2*1H/t21-,22+,25-;;/m1../s1
Canonical SMILES
CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C)=O)C(C)(C)C)=O)=O)C(OCCCCN)=C2.Cl.Cl

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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