Bis-PEG6-acid
CAS No.: 119189-70-7
Cat No.: BP-501249
Purity: ≥95%
4.5 
Bis-PEG6-acid is a bifunctional, PEG-based linker bearing two terminal carboxylic acid groups separated by polyethylene glycol repeat units, providing a flexible, hydrophilic spacer for PROTAC construction. Its chain length and ether-rich backbone help reduce steric constraints between the two conjugated partners and improve solubility in aqueous assay conditions, while the carboxylates enable straightforward amide-bond formation or other coupling strategies to attach an E3-ligase ligand and a target-binding moiety. In PROTAC designs, the linker acts as a molecular “distance and orientation regulator,” allowing the assembled degrader to adopt productive conformations that facilitate ternary complex formation and subsequent ubiquitination-dependent degradation. As a modular component, Bis-PEG6-acid is valuable for systematic linker optimization, particularly when maintaining solubility and minimizing unfavorable intramolecular interactions are critical for evaluating degradation potency and selectivity.
Structure of 119189-70-7
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| Size | Price | Stock | Quantity |
|---|---|---|---|
| 5 g | $999 | In stock | |
| 25 g | $1799 | In stock |
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Bis-PEG6-acid is a polyethylene glycol–based bifunctional linker designed for constructing PROTACs that require controlled spacing and enhanced solubility between a ligand and an E3-recruiting moiety. Its flexible PEG scaffold can improve linker conformational freedom and reduce aggregation, supporting efficient ternary complex formation. The molecule will be described in detail below, including its structural features and practical considerations for PROTAC assembly.
Structure: Bis-PEG6-acid is a PEGylated, dicarboxylic linker featuring ether-rich polyethylene glycol segments that provide flexibility and hydrophilicity. It contains carboxylic acid functional groups suitable for amide or ester formation, with stable C–O and C–C connectivity and no labile inorganic components.
Reactivity: The carboxylic acids are typically activated for coupling to complementary PROTAC fragments via amide-bond formation using standard peptide-coupling chemistries (e.g., carbodiimide-based systems) under mildly basic conditions. Common solvents include polar aprotic media, and reactions are often performed at controlled temperature to limit side reactions. Mechanistically, activation converts the acid into a reactive intermediate that is then attacked by an amine-bearing partner to yield the final conjugate.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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