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VH-298 - CAS 2097381-85-4

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VH-298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd value of 80-90 nM) that could block VHL and HIF-α interactions. VH-298 can be used in PROTAC technology.

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Molecular Formula
C₂₇H₃₃N₅O₄S
Molecular Weight
523.65

VH-298

Catalog Number Size Price Stock Quantity
BP-200030 50 mg $469 In stock
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    • Specification
      • Purity
        ≥98% by HPLC
        Solubility
        DMSO: ≥ 83.3 mg/mL (159.08 mM)
        Application
        Enzyme Inhibitors
        Storage
        Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
        Shipping
        Room temperature in continental US; may vary elsewhere.
        IUPAC Name
        (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
        Synonyms
        (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; EX-A1505; VH 298; VH298; VH-298
    • Properties
      • InChI Key
        NDVQUNZCNAMROD-RZUBCFFCSA-N
        InChI
        InChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
        Canonical SMILES
        CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O
        Pub Chem ID
        122199236
    • Preparing Stock Solutions
      • ConcentrationVolumeMass1 mg5 mg10 mg
        1 mM1.91 mL9.55 mL19.1 mL
        5 mM0.38 mL1.91 mL3.82 mL
        10 mM0.19 mL0.95 mL1.91 mL
        50 mM0.04 mL0.19 mL0.38 mL
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L

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
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