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VH-298 - CAS 2097381-85-4

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Catalog Number	Size	Price	Stock	Quantity
BP-200030	50 mg	$469	In stock

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VH-298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd value of 80-90 nM) that could block VHL and HIF-α interactions. VH-298 can be used in PROTAC technology.

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Molecular Formula

C₂₇H₃₃N₅O₄S

Molecular Weight

523.65

VH-298

- Specification
  - Purity
    
    ≥98% by HPLC
    
    Solubility
    
    In DMSO: ≥ 83.3 mg/mL (159.08 mM)
    * "≥" means soluble, but saturation unknown.
    
    Application
    
    Enzyme Inhibitors
    
    Storage
    
    Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
    
    Synonyms
    
    (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; EX-A1505; VH 298; VH298; VH-298
- Properties
  - InChI Key
    
    NDVQUNZCNAMROD-RZUBCFFCSA-N
    
    InChI
    
    1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
    
    Canonical SMILES
    
    O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4
    
    Pub Chem ID
    
    122199236
- Preparing Stock Solutions
  - ConcentrationVolumeMass 1 mg 5 mg 10 mg
    
    1 mM 1.91 mL 9.55 mL 19.1 mL
    
    5 mM 0.38 mL 1.91 mL 3.82 mL
    
    10 mM 0.19 mL 0.95 mL 1.91 mL
    
    50 mM 0.04 mL 0.19 mL 0.38 mL

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.55 mL	19.1 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
10 mM	0.19 mL	0.95 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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It is commonly abbreviated as: C₁V₁ = C₂V₂

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