Name: Propargyl-PEG5-acid
Brand: BOC Sciences
Price: 398 USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

5 g

$398

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow or Colorless Oily Liquid

ShelfLife

0-4°C for short term (days to weeks), or -20°C for long term (months).

Storage

Store at -20°C, keep in dry and avoid sunlight

Shipping

Room temperature, or blue ice upon request.

IUPACName

3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

4,7,10,13,16-Pentaoxanonadec-18-yn-1-oic acid; Alkyne-PEG5-acid; Propyne-PEG4-CH2CH2COOH; Alkyne-PEG5-COOH; Propargyl-PEG5-COOH; Propargyl-PEG4-CH2CH2COOH; 4,7,10,13,16-pentaoxanonadec-18-ynoic acid

Boiling Point

426.3±45.0°C (Predicted)

Density

1.127±0.06 g/cm3 (Predicted)

InChI Key

GWIACWQVTBMVEI-UHFFFAOYSA-N

InChI

InChI=1S/C14H24O7/c1-2-4-17-6-8-19-10-12-21-13-11-20-9-7-18-5-3-14(15)16/h1H,3-13H2,(H,15,16)

SMILES

C#CCOCCOCCOCCOCCOCCC(=O)O

Propargyl-PEG5-acid, is designed to provide a flexible polyethylene glycol spacer terminating in a reactive carboxylic acid and a propargyl handle for orthogonal conjugation. Its PEG-based architecture supports favorable solubility and conformational adaptability in targeted protein degradation constructs, while the acid functionality enables robust coupling to ligands. The detailed structural and reactivity characteristics are provided below.

Structure: The linker comprises a propargyl group connected to a polyethylene glycol chain, capped by a carboxylic acid. It contains ether linkages within the PEG segment, a terminal alkyne for click-type chemistry, and a carboxylate-bearing functional group capable of forming amide or ester derivatives. These features promote water compatibility and chemical versatility.

Reactivity: The propargyl terminus is suitable for copper-catalyzed azide–alkyne cycloaddition, enabling efficient conjugation to azide-functional partners under standard click conditions. The carboxylic acid can be activated for amide bond formation using common coupling reagents, typically in polar aprotic solvents with base to drive nucleophilic acyl substitution. Orthogonal sequencing allows stepwise assembly of PROTACs with controlled linker–ligand connectivity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂