GALC (Galactosylceramidase)

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GALC (Galactosylceramidase) is an enzyme encoded by the GALC gene in humans. The enzyme uses water molecules to break down certain fats (called galactosolipids), which are mainly found in the nervous system and kidneys. In cells, galactosylceramidase is present in enzyme-filled sacs called lysosomes, where it hydrolyzes specific galactosyllipids, including galactosylceramides and psychotropic drugs. Galactose ceramide is an important component of myelin, which is the protective layer around some nerve cells to ensure the rapid transmission of nerve impulses. The decomposition of galactosidase by ceramidase is part of the normal renewal of myelin that occurs in a lifetime. Diseases associated with GALC include Krabbe disease and leukodystrophy.

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