1-Methanesulfonyl-11-hydroxy-3,6,9-trioxaundecane - CAS 65883-12-7

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PEG4-Ms is a polyethylene glycol (PEG)-based PROTAC linker. PEG4-Ms can be used in the synthesis of a series of PROTACs.

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Molecular Formula

C20H20O7S

Molecular Weight

256.32

1-Methanesulfonyl-11-hydroxy-3,6,9-trioxaundecane

- Specification
  - Appearance
    
    Brown Oily Residue
    
    Storage
    
    Please store the product under the recommended conditions in the Certificate of Analysis.
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
    
    Synonyms
    
    1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
- Properties
  - InChI Key
    
    YCKREPSOVRTYRC-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C9H20O7S/c1-17(11,12)16-9-8-15-7-6-14-5-4-13-3-2-10/h10H,2-9H2,1H3
    
    Canonical SMILES
    
    CS(=O)(=O)OCCOCCOCCOCCO
- Reference Reading
  - 1. Lack of effectiveness of several chelators in removing internally deposited strontium from mice following repeated parenteral strontium administration
    
    J M Llobet, M T Colomina, J L Domingo, J Corbella Vet Hum Toxicol. 1992 Feb;34(1):7-9.
    
    Diethylenetriaminepentaacetic acid (DTPA), ethylenglycolbis-(beta-amino-ethylether)-N,N-tetraacetic acid (EGTA), tartaric acid, KRYPTOFIX 222, and KRYPTOFIX 5 were evaluated for their efficacy in mobilization of strontium from the body of mice which had received 20 sc injections of strontium nitrate (95 mg/kg/injection) for 4 w. Twenty-four hours after the last strontium injection, ip administration of 1 of the various chelators or 0.9% saline was initiated and continued daily for 5 d. Mice were housed in metabolic cages, and urine and feces were collected daily for 5 d. After this period, the animals were killed and tissues removed. Tartaric acid, KRYPTOFIX 222, and KRYPTOFIX 5 had no effect on urinary or fecal strontium elimination, whereas DTPA and EGTA significantly decreased the fecal strontium excretion. The concentration of strontium in bone was only lowered in tartaric-treated mice. This study indicates the use of the above chelators is not an effective treatment to enhance the removal of strontium following repeated parenteral strontium administration.

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