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Fmoc-N-amido-PEG2-propionic acid - CAS 872679-70-4

Inquiry

Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Molecular Formula

C22H25NO6

Molecular Weight

399.44

Fmoc-N-amido-PEG2-propionic acid

- Specification
  - Related CAS
    
    850312-72-0 (polymer)
    
    Purity
    
    ≥95%
    
    Solubility
    
    Soluble in DMSO, Methanol
    
    Appearance
    
    Colorless Oily Matter
    
    Storage
    
    Store at 2-8°C
    
    Shipping
    
    Room temperature
    
    IUPAC Name
    
    3-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]propanoic acid
    
    Synonyms
    
    Fmoc-N-amido-PEG2-acid; Fmoc-9-Amino-4,7-Dioxanonanoic acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oic acid; Fmoc-AEEP-OH; 13-(9H-Fluoren-9-yl)-11-oxo-4,7,12-trioxa-10-azatridecanoic Acid;?Fmoc-NH-PEG2-CH2CH2COOH; 9-(Fmoc-amino)-4,7-dioxanonanoic Acid; 2,7,10-Trioxa-4-azatridecan-13-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-; Fmoc-NH-PEG2-COOH; Fmoc-NH-PEG2-acid; Fmoc-PEG2-propionic acid; 3-[2-[2-(Fmoc-amino)ethoxy]ethoxy]propionic Acid; 9-(9H-Fluorene-9-ylmethoxycarbonylamino)-4,7-dioxanonanoic acid
- Properties
  - Boiling Point
    
    622.1±55.0°C at 760 mmHg
    
    Melting Point
    
    95.0-99.0°C
    
    Density
    
    1.243±0.06 g/cm3 at 20°C, 760 Torr
    
    InChI Key
    
    QWHLFJJLRVOHTM-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C22H25NO6/c24-21(25)9-11-27-13-14-28-12-10-23-22(26)29-15-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-8,20H,9-15H2,(H,23,26)(H,24,25)
    
    Canonical SMILES
    
    C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCC(=O)O
    
    Biological Activity
    
    Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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