Name: Fmoc-N-amido-PEG2-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO, Methanol

Appearance

Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

3-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]propanoic acid

Synonyms

Fmoc-N-amido-PEG2-acid; Fmoc-9-Amino-4,7-Dioxanonanoic acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oic acid; Fmoc-AEEP-OH; 13-(9H-Fluoren-9-yl)-11-oxo-4,7,12-trioxa-10-azatridecanoic Acid;?Fmoc-NH-PEG2-CH2CH2COOH; 9-(Fmoc-amino)-4,7-dioxanonanoic Acid; 2,7,10-Trioxa-4-azatridecan-13-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-; Fmoc-NH-PEG2-COOH; Fmoc-NH-PEG2-acid; Fmoc-PEG2-propionic acid; 3-[2-[2-(Fmoc-amino)ethoxy]ethoxy]propionic Acid; 9-(9H-Fluorene-9-ylmethoxycarbonylamino)-4,7-dioxanonanoic acid

Boiling Point

622.1±55.0°C at 760 mmHg

Melting Point

95.0-99.0°C

Density

1.243±0.06 g/cm3 at 20°C, 760 Torr

InChI Key

QWHLFJJLRVOHTM-UHFFFAOYSA-N

InChI

InChI=1S/C22H25NO6/c24-21(25)9-11-27-13-14-28-12-10-23-22(26)29-15-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-8,20H,9-15H2,(H,23,26)(H,24,25)

SMILES

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCC(=O)O

Biological Activity

Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Fmoc-N-amido-PEG2-propionic acid, provides a PEG-based spacer that can enhance solubility and tune the effective distance and orientation between binding modules in targeted protein degradation constructs. Its Fmoc-protected amide functionality supports controlled stepwise conjugation, enabling reproducible assembly of heterobifunctional degraders. The detailed structural and synthetic considerations below describe how this linker is typically handled and incorporated into PROTAC workflows.

Structure: The molecule contains an Fmoc-protected amide linked to a short PEG spacer and a terminal propionic acid group. It features aromatic carbamate protection, ether-rich poly(ethylene glycol) connectivity, and a carboxylic acid for coupling. Overall, it is a flexible, polar, and hydrogen-bonding capable linker.

Reactivity: The terminal carboxylic acid is suited for amide-bond formation using standard coupling chemistries, typically activated carboxylates with coupling reagents and base in polar aprotic solvents. The Fmoc group is removable under mild base conditions to expose an amine for subsequent conjugation. In PROTAC assembly, this supports sequential coupling strategies that preserve PEG spacer integrity and enable controlled linker installation.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂