Bis-PEG5-acetic acid

 CAS No.: 77855-76-6  Cat No.: BP-500023  Purity: ≥95% 4.5  

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. PEG6-(CH2CO2H)2 is a PEG derivative containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Bis-PEG5-acetic acid

Structure of 77855-76-6

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Category
PROTAC Linker
Molecular Formula
C14H26O10
Molecular Weight
354.35
Appearance
Colorless Oily Liquid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO, Water
Appearance
Colorless Oily Liquid
Storage
Store at 2-8°C
Shipping
Room temperature in continental US; may vary elsewhere
IUPACName
2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Synonyms
COOH-CH2-PEG6-CH2-COOH; COOH-CH2-PEG5-CH2-COOH; 3,6,9,12,15,18-Hexaoxaeicosanedioic acid; 3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid
Boiling Point
524.8±45.0 °C at 760 mmHg
Density
1.234±0.06 g/cm3 (Predicted)
InChI Key
DCQRSABUSOYSIY-UHFFFAOYSA-N
InChI
InChI=1S/C14H26O10/c15-13(16)11-23-9-7-21-5-3-19-1-2-20-4-6-22-8-10-24-12-14(17)18/h1-12H2,(H,15,16)(H,17,18)
Canonical SMILES
C(COCCOCCOCC(=O)O)OCCOCCOCC(=O)O

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: PHA665752 | PROTAC Mcl1 degrader-1 | HO-PEG21-OH | PND-1186 (VS-4718) | dFKBP-1 | Ursolic acid | ARV-471 | CP-7 | Lenalidomide hydrochloride | Chloroacetamido-PEG4-t-butyl ester | Bis-PEG5-acetic acid

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