VL285

Background Introduction

VL285 is a small-molecule ligand specifically designed to bind Von Hippel-Lindau (VHL) E3 ubiquitin ligase. The VHL E3 ligase is instrumental in the ubiquitin-proteasome system, a pathway responsible for targeted protein degradation within cells. VHL ligands such as VL285 have become foundational components in the design of PROTACs (Proteolysis Targeting Chimeras), enabling the selective removal of pathologically relevant proteins and facilitating the generation of next-generation therapeutics.

Mechanism

VL285 acts by binding to the VHL E3 ubiquitin ligase complex, thereby recruiting VHL in proximity to a target protein of interest when incorporated into a PROTAC molecule. Upon formation of the ternary complex (target protein-PROTAC-E3 ligase), VL285-mediated VHL engagement triggers the tagging (ubiquitination) of the target protein, marking it for rapid proteasomal degradation. The precision and stability offered by VL285 allow for optimal linker placement and increased success rates in protein knockdown assays.

Applications

VL285 is widely used for the construction of VHL-based PROTACs and small-molecule degraders across research and drug discovery sectors. Its specific binding characteristics and chemical tractability make it a go-to intermediate for:

• Synthesis of PROTAC molecules targeting a vast array of intracellular proteins
• Development of VHL-recruiting molecular glues and targeted protein degradation platforms
• Structure-activity relationship (SAR) studies optimizing degrader efficacy
• Creation of custom protein knockdown tools for target validation, functional genomics, and pharmacological research
• Partnering with biotech companies and academic labs for bespoke PROTAC design and high-throughput screening platforms

• High-purity compound verified by HPLC, NMR, and LC-MS
• Consistent batch-to-batch reproducibility with complete QC documentation
• Supplied with COA, MSDS, and analytical data for traceability
• Reliable global shipping with stability-guaranteed packaging
• Dedicated technical support and optional custom synthesis service
• Demonstrates strong binding affinity to CRBN, VHL, or other E3 ligases
• Enables stable E3 ligase recruitment for targeted protein degradation
• Highly selective VHL E3 ligase ligand enables targeted protein degradation with minimal off-target effects.
• Optimized for superior cell permeability and metabolic stability, facilitating efficient PROTAC design.